Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging

被引:51
作者
Ren, Chi [1 ,2 ]
Komiyama, Takaki [1 ,2 ]
机构
[1] Univ Calif San Diego, Neurobiol Sect, Ctr Neural Circuits & Behav, Dept Neurosci, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Halicioglu Data Sci Inst, La Jolla, CA 92093 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
decision making; large-scale cortical dynamics; learning; multimodal recordings; sensorimotor integration; wide-field calcium imaging; NEURAL ACTIVITY; CORTICAL ACTIVITY; FUNCTIONAL ARCHITECTURE; ELECTRICAL-ACTIVITY; PATTERNED ACTIVITY; NEURONAL-ACTIVITY; TRANSGENIC MICE; IN-VIVO; ORGANIZATION; VOLTAGE;
D O I
10.1523/JNEUROSCI.3003-20.2021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The brain functions through coordinated activity among distributed regions. Wide-field calcium imaging, combined with improved genetically encoded calcium indicators, allows sufficient signal-to-noise ratio and spatiotemporal resolution to afford a unique opportunity to capture cortex-wide dynamics on a moment-by-moment basis in behaving animals. Recent applications of this approach have been uncovering cortical dynamics at unprecedented scales during various cognitive processes, ranging from relatively simple sensorimotor integration to more complex decision-making tasks. In this review, we will highlight recent scientific advances enabled by wide-field calcium imaging in behaving mice. We then summarize several technical considerations and future opportunities for wide-field imaging to uncover large-scale circuit dynamics.
引用
收藏
页码:4160 / 4168
页数:9
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