Can we predict protein from mRNA levels?

被引：156

作者：

Fortelny, Nikolaus ^{[1
,2
,3
]}

Overall, Christopher M. ^{[1
,3
,4
]}

Pavlidis, Paul ^{[2
,5
]}

Freue, Gabriela V. Cohen ^{[6
]}

机构：

[1] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC, Canada

[2] Univ British Columbia, Michael Smith Labs, Vancouver, BC, Canada

[3] Univ British Columbia, Ctr Blood Res, Vancouver, BC, Canada

[4] Univ British Columbia, Dept Oral Biol & Med Sci, Vancouver, BC, Canada

[5] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[6] Univ British Columbia, Dept Stat, Vancouver, BC, Canada

来源：

NATURE | 2017年 / 547卷 / 7664期

关键词：

D O I：

10.1038/nature22293

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：E19 / E22

页数：4

共 9 条

[1] Berman S., 2012, Significance
[2] Gene-specific correlation of RNA and protein levels in human cells and tissues
Edfors, Fredrik
Danielsson, Frida
Hallstrom, Bjorn M.
Kall, Lukas
Lundberg, Emma
Ponten, Fredrik
Forsstrom, Bjorn
Uhlen, Mathias
[J]. MOLECULAR SYSTEMS BIOLOGY, 2016, 12 (10)
[3] Elliptical Insights: Understanding Statistical Methods through Elliptical Geometry
Friendly, Michael
Monette, Georges
Fox, John
[J]. STATISTICAL SCIENCE, 2013, 28 (01) : 1 - 39
[4] Hocking RR, 2013, Methods and applications of linear models: regression and the analysis of variance
[5] Statistics requantitates the central dogma
Li, Jingyi Jessica
Biggin, Mark D.
[J]. SCIENCE, 2015, 347 (6226) : 1066 - 1067
[6] System wide analyses have underestimated protein abundances and the importance of transcription in mammals
Li, Jingyi Jessica
Bickel, Peter J.
Biggin, Mark D.
[J]. PEERJ, 2014, 2 : 1 - 26
[7] On the Dependency of Cellular Protein Levels on mRNA Abundance
Liu, Yansheng
Beyer, Andreas
Aebersold, Ruedi
[J]. CELL, 2016, 165 (03) : 535 - 550
[8] Global quantification of mammalian gene expression control
Schwanhaeusser, Bjoern
Busse, Dorothea
Li, Na
Dittmar, Gunnar
Schuchhardt, Johannes
Wolf, Jana
Chen, Wei
Selbach, Matthias
[J]. NATURE, 2011, 473 (7347) : 337 - 342
[9] Mass-spectrometry-based draft of the human proteome
Wilhelm, Mathias
Schlegl, Judith
Hahne, Hannes
Gholami, Amin Moghaddas
Lieberenz, Marcus
Savitski, Mikhail M.
Ziegler, Emanuel
Butzmann, Lars
Gessulat, Siegfried
Marx, Harald
Mathieson, Toby
Lemeer, Simone
Schnatbaum, Karsten
Reimer, Ulf
Wenschuh, Holger
Mollenhauer, Martin
Slotta-Huspenina, Julia
Boese, Joos-Hendrik
Bantscheff, Marcus
Gerstmair, Anja
Faerber, Franz
Kuster, Bernhard
[J]. NATURE, 2014, 509 (7502) : 582 - +

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