Can we predict protein from mRNA levels?

被引：166

作者：

Fortelny, Nikolaus ^{[1
,2
,3
]}

Overall, Christopher M. ^{[1
,3
,4
]}

Pavlidis, Paul ^{[2
,5
]}

Freue, Gabriela V. Cohen ^{[6
]}

机构：

[1] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC, Canada

[2] Univ British Columbia, Michael Smith Labs, Vancouver, BC, Canada

[3] Univ British Columbia, Ctr Blood Res, Vancouver, BC, Canada

[4] Univ British Columbia, Dept Oral Biol & Med Sci, Vancouver, BC, Canada

[5] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[6] Univ British Columbia, Dept Stat, Vancouver, BC, Canada

来源：

NATURE | 2017年 / 547卷 / 7664期

关键词：

D O I：

10.1038/nature22293

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：E19 / E22

页数：4

共 9 条

[1]

Berman S., 2012, Significance

[2] Gene-specific correlation of RNA and protein levels in human cells and tissues [J].

Edfors, Fredrik ;

Danielsson, Frida ;

Hallstrom, Bjorn M. ;

Kall, Lukas ;

Lundberg, Emma ;

Ponten, Fredrik ;

Forsstrom, Bjorn ;

Uhlen, Mathias .

MOLECULAR SYSTEMS BIOLOGY, 2016, 12 (10)

[3] Elliptical Insights: Understanding Statistical Methods through Elliptical Geometry [J].

Friendly, Michael ;

Monette, Georges ;

Fox, John .

STATISTICAL SCIENCE, 2013, 28 (01) :1-39

[4]

Hocking RR, 2013, Methods and applications of linear models: regression and the analysis of variance

[5] Statistics requantitates the central dogma [J].

Li, Jingyi Jessica ;

Biggin, Mark D. .

SCIENCE, 2015, 347 (6226) :1066-1067

[6] System wide analyses have underestimated protein abundances and the importance of transcription in mammals [J].

Li, Jingyi Jessica ;

Bickel, Peter J. ;

Biggin, Mark D. .

PEERJ, 2014, 2 :1-26

[7] On the Dependency of Cellular Protein Levels on mRNA Abundance [J].

Liu, Yansheng ;

Beyer, Andreas ;

Aebersold, Ruedi .

CELL, 2016, 165 (03) :535-550

[8] Global quantification of mammalian gene expression control [J].

Schwanhaeusser, Bjoern ;

Busse, Dorothea ;

Li, Na ;

Dittmar, Gunnar ;

Schuchhardt, Johannes ;

Wolf, Jana ;

Chen, Wei ;

Selbach, Matthias .

NATURE, 2011, 473 (7347) :337-342

[9] Mass-spectrometry-based draft of the human proteome [J].

Wilhelm, Mathias ;

Schlegl, Judith ;

Hahne, Hannes ;

Gholami, Amin Moghaddas ;

Lieberenz, Marcus ;

Savitski, Mikhail M. ;

Ziegler, Emanuel ;

Butzmann, Lars ;

Gessulat, Siegfried ;

Marx, Harald ;

Mathieson, Toby ;

Lemeer, Simone ;

Schnatbaum, Karsten ;

Reimer, Ulf ;

Wenschuh, Holger ;

Mollenhauer, Martin ;

Slotta-Huspenina, Julia ;

Boese, Joos-Hendrik ;

Bantscheff, Marcus ;

Gerstmair, Anja ;

Faerber, Franz ;

Kuster, Bernhard .

NATURE, 2014, 509 (7502) :582-+

← 1 →