Complex Shear Modulus of Hydrogels Using a Dynamic Nanoindentation Method

被引：7

作者：

Akhtar, Riaz ^{[1
]}

Draper, Emily R. ^{[2
]}

Adams, Dave J. ^{[2
]}

Pfaff, Holger ^{[3
]}

机构：

[1] Univ Liverpool, Sch Engn, Ctr Mat & Struct, Liverpool L69 3GH, Merseyside, England

[2] Univ Liverpool, Dept Chem, Ctr Mat Discovery, Liverpool L69 7ZD, Merseyside, England

[3] Keysight Technol GmbH, Lyoner Str 20, D-60528 Frankfurt, Germany

来源：

MECHANICS OF BIOLOGICAL SYSTEMS AND MATER IALS, VOL 6 | 2016年

关键词：

Nanoindentation; Hydrogels; Shear modulus; Dynamic indentation; MECHANICAL CHARACTERIZATION; VISCOELASTIC SOLIDS; SOFT; TISSUES; TIME;

D O I：

10.1007/978-3-319-21455-9_17

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The micromechanical properties of soft tissues and materials are of considerable interest for biomedical applications. Nanoindentation is a powerful technique for determining localized material properties of biological tissues and has been used widely for hard tissue and material characterization. However, the technique is much more challenging when utilized for soft tissues due to their compliance as well as due to the limitations of commercial instruments which were originally developed for stiff, engineering materials. This study explores the use of a dynamic indentation method with a cylindrical punch (100 mu m diameter) to characterize gelatin gel and low molecular weight hydrogels. A Keysight Technologies DCM II actuator is used with the Continuous Stiffness Measurement (CSM) to determine the complex shear modulus of these gels. The method overcomes surface detection issues with standard quasi-static nanoindentation as a change in phase angle can be used to accurately detect the sample surface. The data collected in this study are found to be comparable with macroscopic rheology and demonstrates the utility of the method for characterization of hydrogels.

引用

页码：141 / 145

页数：5

共 13 条

[11] GLUCOSE DETERMINATION BY A PULSED PHOTOACOUSTIC TECHNIQUE - AN EXPERIMENTAL-STUDY USING A GELATIN-BASED TISSUE PHANTOM [J].