Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China

被引：26

作者：

Chu, Daniel K. W. ^{[1
]}

Hui, Kenrie P. Y. ^{[1
]}

Gu, Haogao ^{[1
]}

Ko, Ronald L. W. ^{[1
]}

Krishnan, Pavithra ^{[1
]}

Ng, Daisy Y. M. ^{[1
]}

Liu, Gigi Y. Z. ^{[1
]}

Wan, Carrie K. C. ^{[1
]}

Cheung, Man-Chun ^{[1
]}

Ng, Ka-Chun ^{[1
]}

Nicholls, John M. ^{[1
]}

Tsang, Dominic N. C. ^{[2
]}

Peiris, Malik ^{[1
]}

Chan, Michael C. W. ^{[1
]}

Poon, Leo L. M. ^{[1
]}

机构：

[1] Univ Hong Kong, Hong Kong, Peoples R China

[2] Dept Hlth, Hong Kong, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 05期

关键词：

D O I：

10.3201/eid2705.210015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.

引用

页码：1492 / 1495

页数：4

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