Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG)

被引：206

作者：

Biganzoli, Laura ^{[1
]}

Battisti, Nicole Matteo Luca ^{[2
,3
]}

Wildiers, Hans ^{[4
]}

McCartney, Amelia ^{[5
]}

Colloca, Giuseppe ^{[6
]}

Kunkler, Ian H. ^{[7
]}

Cardoso, Maria-Joao ^{[8
,9
]}

Cheung, Kwok-Leung ^{[10
]}

de Glas, Nienke Aafke ^{[11
]}

Trimboli, Rubina M. ^{[12
]}

Korc-Grodzicki, Beatriz ^{[13
]}

Soto-Perez-de-Celis, Enrique ^{[14
]}

Ponti, Antonio ^{[15
]}

Tsang, Janice ^{[16
]}

Marotti, Lorenza ^{[17
]}

Benn, Karen ^{[18
]}

Aapro, Matti S. ^{[19
]}

Brain, Etienne G. C. ^{[20
,21
]}

机构：

[1] Hosp Prato, Dept Med Oncol, I-59100 Prato, Italy

[2] Royal Marsden NHS Fdn Trust, Dept Med, Breast Unit, London, England

[3] Inst Canc Res, Breast Canc Res Div, London, England

[4] Univ Hosp Leuven, Dept Gen Med Oncol, Leuven, Belgium

[5] Hosp Prato, Dept Med Oncol, Prato, Italy

[6] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncol, Operat Complessa Radioterapia Oncol, Rome, Italy

[7] Western Gen Hosp Campus, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland

[8] Champalimaud Fdn, Champalimaud Clin Ctr, Breast Unit, Lisbon, Portugal

[9] Nova Med Sch, Lisbon, Portugal

[10] Univ Nottingham, Sch Med, Nottingham, England

[11] Leiden Univ, Med Ctr, Dept Med Oncol, Leiden, Netherlands

[12] Humanitas Clin & Res Ctr, Unit Radiol, Rozzano, Italy

[13] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[14] Inst Nacl Ciencias Med Nutr Salvador Zubiran, Dept Geriatr, Mexico City, DF, Mexico

[15] AOU Citta Salute & Sci, CPO Piemonte, Turin, Italy

[16] Univ Hong Kong, Li Ka Shing Fac Med, Hong Kong Breast Oncol Grp, Hong Kong, Peoples R China

[17] European Soc Breast Canc Specialists, Florence, Italy

[18] EUROPA DONNA European Breast Canc Coalit, Milan, Italy

[19] Clin Genolier, Genolier Canc Ctr, Genolier, Switzerland

[20] Inst Curie, Dept Med Oncol, St Cloud, France

[21] Inst Curie, Dept Med Oncol, Paris, France

来源：

LANCET ONCOLOGY | 2021年 / 22卷 / 07期

关键词：

RANDOMIZED CONTROLLED-TRIAL; REGIONAL NODAL IRRADIATION; ADJUVANT CHEMOTHERAPY; ENDOCRINE THERAPY; ELDERLY-PATIENTS; CONSERVING SURGERY; OPEN-LABEL; FOLLOW-UP; AROMATASE INHIBITORS; CLINICAL ONCOLOGY;

D O I：

10.1016/S1470-2045(20)30741-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficient evidence specific to older adults. Decision making should not be driven by age alone but should involve geriatric assessments plus careful consideration of life expectancy, competing risks of mortality, and patient preferences. A multidisciplinary taskforce, including members of the European Society of Breast Cancer Specialists and International Society of Geriatric Oncology, gathered to expand and update the previous 2012 evidence-based recommendations for the management of breast cancer in older individuals with the endorsement of the European Cancer Organisation. These guidelines were expanded to include chemotherapy toxicity prediction calculators, cultural and social considerations, surveillance imaging, genetic screening, gene expression profiles, neoadjuvant systemic treatment options, bone-modifying drugs, targeted therapies, and supportive care. Recommendations on geriatric assessment, ductal carcinoma in situ, screening, primary endocrine therapy, surgery, radiotherapy, adjuvant systemic therapy, and secondary breast cancer were updated.

引用

页码：E327 / E340

页数：14

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