Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L.

被引：106

作者：

Putalun, Waraporn ^{[1
]}

Luealon, Wanwimon

De-Eknamkul, Wanchai

Tanaka, Hiroyuki

Shoyama, Yukihiro

机构：

[1] Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen 40002, Thailand

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok 10330, Thailand

[3] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, Fukuoka 8128582, Japan

来源：

BIOTECHNOLOGY LETTERS | 2007年 / 29卷 / 07期

基金：

日本学术振兴会;

关键词：

Artemisia annua L; artemisinin; elicitors; hairy roots;

D O I：

10.1007/s10529-007-9368-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Artemisinin production by hairy roots of Artemisia annua L. was increased 6-fold to 1.8 mu g mg(-1) dry wt over 6 days by adding 150 mg chitosan l(-1). The increase was dose-dependent. Similar treatment of hairy roots with methyl jasmonate (0.2 mM) or yeast extract (2 mg ml(-1)) increased artemisinin production to 1.5 and 0.9 mu g mg(-1) dry wt, respectively.

引用

页码：1143 / 1146

页数：4

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