Analysis of Various Organic and Organometallic Compounds Using Nanostructure-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (NALDI-TOFMS)

被引：39

作者：

Wyatt, Mark F. ^{[1
]}

Ding, Shujing ^{[1
]}

Stein, Bridget K. ^{[1
]}

Brenton, A. Gareth ^{[1
]}

Daniels, R. Hugh ^{[2
]}

机构：

[1] Swansea Univ, Sch Med, IMS, EPSRC Natl Mass Spectrometry Serv Ctr, Swansea SA2 8PP, W Glam, Wales

[2] Nanosys Inc, Palo Alto, CA USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2010年 / 21卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

SILICON NANOWIRES; POROUS SILICON; MATRIX; DESORPTION; MOLECULES; PEPTIDES; ARRAYS; TARGET;

D O I：

10.1016/j.jasms.2010.03.038

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nartostructure-assisted laser desorption/ionization time-of-flight mass spectrometry (NALDI-TOFMS) has been developed recently as a matrix-free/surface-assisted alternative to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). The NALDI surface of silicon nanowires is already very effective for the analysis of small to medium sized, polar organic molecules in positive ion mode. The current study examined this technology for the analysis of several nonpolar organic, organometallic, and ionic compounds in positive ion mode, as well as a fluorinated compound and various acids in negative ion mode. NALDI data are compared and contrasted with MALDI data for the same compounds, and the higher sensitivity of NALDI is highlighted by the successful characterization of two porphyrins for a sample amount of 10 amol per spot. (J Am Soc Mass Spectrom 2010, 21, 1256-1259) (C) 2010 American Society for Mass Spectrometry

引用

页码：1256 / 1259

页数：4

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