Mechanism of CINC-1 production from gastric epithelial cells stimulated with TNF-α

被引：0

作者：

Handa, O ^{[1
]}

Naito, Y ^{[1
]}

Takagi, T ^{[1
]}

Ueda, M ^{[1
]}

Ishikawa, T ^{[1
]}

Imamoto, E ^{[1
]}

Tomatsuri, N ^{[1
]}

Uchiyama, K ^{[1
]}

Shimozawa, M ^{[1
]}

Katada, K ^{[1
]}

Ueda, T ^{[1
]}

Kokura, S ^{[1
]}

Ichikawa, H ^{[1
]}

Yoshida, N ^{[1
]}

Yoshikawa, T ^{[1
]}

Gediminas, C ^{[1
]}

Kvietys, PR ^{[1
]}

机构：

[1] Lawson Hlth Res Inst, Vasc Cell Biol Inflammat Program, London, ON, Canada

来源：

XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2002年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CINC-1 has been suggested to play a role as a mediator of inflammatory reactions with neutrophil infiltration in rats. In this study, e investigate the mechanism of CINC-1 production from rat gastric mucosal cell (RGM-1) in response to TNF-alpha stimulation in vitro. TNF-alpha stimulation results in, 1) up-regulation of CINC-1 mRNA and protein, 2) NF-kappaB p65 activation, and 3) increase in cH(2)DCF-DA oxidation. These changes were reversed by several inhibitors against NF-kappaB activation, endogenous reactive oxygen production. In conclusion, TNF-alpha-induced CINC-1 production from RGM-1 cells depends on NF-kappaB and oxidative stress.

引用

页码：347 / 350

页数：4

共 3 条

[1] Oxidative stress interference with the nuclear factor-κB activation pathways [J].

Schoonbroodt, S ;

Piette, J .

BIOCHEMICAL PHARMACOLOGY, 2000, 60 (08) :1075-1083

[2] Inhibition of the production of rat cytokine-induced neutrophil chemoattractant (CINC)-1, a member of the interleukin-8 family, by adenovirus-mediated overexpression of IκBα [J].

Takaishi, K ;

Ohtsuka, T ;

Tsuneyoshi, S ;

Maehara, N ;

Harada, M ;

Yoshida, H ;

Watanabe, K ;

Tsurufuji, S .

JOURNAL OF BIOCHEMISTRY, 2000, 127 (03) :511-516

[3] Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1 [J].

Teshima, S ;

Kutsumi, H ;

Kawahara, T ;

Kishi, K ;

Rokutan, K .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 279 (06) :G1169-G1176

← 1 →