ADME/PK as part of a rational approach to drug discovery

被引:167
作者
Eddershaw, PJ [1 ]
Beresford, AP [1 ]
Bayliss, MK [1 ]
机构
[1] Glaxo Wellcome Res & Dev Ltd, Bioanal & Drug Metab, Ware SG12 0DP, Herts, England
关键词
D O I
10.1016/S1359-6446(00)01540-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Rational drug discovery requires an early appraisal of all factors impacting on the likely success of a drug candidate in the subsequent preclinical, clinical and commercial phases of drug development. The study of absorption, distribution, metabolism, excretion and pharmacokinetics (ADME/PK) has developed into a relatively mature discipline in drug discovery through the application of well-established in vitro and in vivo methodologies. The availability of improved analytical and automation technologies has dramatically increased our ability to dissect out the fundamentals of ADME/PK through the development of increasingly powerful in silico methods. This is fuelling a shift away from the traditional, empirical nature of ADME/PK towards a more rational, in cerebro approach to drug design.
引用
收藏
页码:409 / 414
页数:6
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