Neutralizing immunity against SARS-CoV-2 Omicron BA.1 by infection and vaccination

被引：9

作者：

Duan, Li-Jun ^{[1
]}

Jiang, Wen-Gu ^{[2
]}

Wang, Zhuang-Ye ^{[3
]}

Yao, Lin ^{[1
]}

Zhu, Ka-Li ^{[1
]}

Meng, Qing-Chuan ^{[4
]}

Wang, Bao-Shan ^{[5
]}

Li, Li-Bo ^{[2
]}

Wang, Guo-Lin ^{[1
]}

Ma, Mai-Juan ^{[1
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[2] Jining Ctr Dis Control & Prevent, Jining, Peoples R China

[3] Jining Ctr Dis Control & Prevent, Dezhou, Peoples R China

[4] Ningjin Cty Community Hlth Serv Ctr, Dezhou, Peoples R China

[5] Decheng Dist Ctr Dis Control & Prevent, Dezhou, Peoples R China

来源：

ISCIENCE | 2022年 / 25卷 / 09期

基金：

北京市自然科学基金;

关键词：

RESPONSES; VACCINES;

D O I：

10.1016/j.isci.2022.104886

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The emergence of the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant has raised questions regarding resistance to neutralizing antibodies elicited by natural infection or immunization. We examined the neutralization activity of sera collected from previously SARS-CoV-2-infected individuals and SARS-CoV-2 naive individuals who received BBIBP-CorV or CoronaVac to BA.1 and the earlier variants Alpha, Beta, and Delta. Both sera from convalescent patients over three months after infection and two-dose BBIBP-CorV or CoronaVac vaccine recipients barely inhibited BA.1, less effectively neutralized Beta and Delta, and moderately neutralized Alpha. However, administering a single dose of BBIBP-CorV or CoronaVac in previously infected individuals or a third dose booster vaccination of BBIBP-CorV or CoronaVac in previously vaccinated individuals enhances neutralizing activity against BA.1 and other variants, albeit with a lower antibody titer for BA.1. Our data suggest that a booster vaccination is important to broaden neutralizing antibody responses against the variants.

引用

页数：14

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