The corridor task:: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease

被引：13

作者：

Dobrossy, Mate D. ^{[1
]}

Dunnett, Stephen B. ^{[1
]}

机构：

[1] Univ Cardiff Wales, Brain Repair Grp, Sch Biosci, Cardiff CF10 3US, Wales

来源：

BEHAVIOURAL BRAIN RESEARCH | 2007年 / 179卷 / 02期

基金：

英国医学研究理事会;

关键词：

corridor task; striatal lesions; embryonic grafts; Huntington's disease; neurotransplantation;

D O I：

10.1016/j.bbr.2007.02.030

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：326 / 330

页数：5

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