共 13 条
Novel bone regeneration matrix for next-generation biomaterial using a vertical array of carbonated hydroxyapatite nanoplates coated onto electrospun nylon 6 nanofibers
被引:18
作者:
Abdal-hay, Abdalla
[1
,2
,3
]
Hamdy, Abdel Salam
[4
]
Morsi, Yosry
[5
]
Khalil, Khalil Abdelrazek
[6
,7
]
Lim, Ju Hyun
[8
]
机构:
[1] South Valley Univ, Fac Engn, Dept Engn Mat & Mech Design, Qena, Egypt
[2] Chonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
[3] Univ Cuenca, Fac Engn, Dept Comp Sci, Cuenca, Ecuador
[4] Univ Texas Pan Amer, Coll Engn & Comp Sci, Dept Mfg Engn, Edinburg, TX 78541 USA
[5] Swinburne Univ Technol, Fac Sci Engn & Technol, Dept Biomech & Tissue Engn Grp, Melbourne, Vic 3122, Australia
[6] King Saud Univ, Coll Engn, Dept Mech Engn, Riyadh 11421, Saudi Arabia
[7] Aswan Univ, Fac Energy Engn, Dept Mech Engn, Aswan, Egypt
[8] Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Urol, Kangnung, South Korea
关键词:
Nanostructures;
Biomaterials;
Nanofibers;
Hydroxyapatite nanoplates;
Bone-regeneration;
Electrospun nylon 6;
MEMBRANE;
D O I:
10.1016/j.matlet.2014.09.034
中图分类号:
T [工业技术];
学科分类号:
08 ;
摘要:
For the first time, a novel method for nucleation and deposition of vertically arrayed carbonated hydroxyapatite (HA) nanoplates without obvious agglomeration onto the post-electrospun nylon 6 (N6) nanofibers was successfully designed. The technique is based on a simple hydrothermal treatment of the fabricated N6 mat. The excellent bioactivity of the treated scaffold was confirmed in vitro within MC3T3-E1 osteoblastic cells by significant attachment and in-growth activity on the treated scaffold, and the ability to differentiate into osteoblastic cells with excellent osteogenic potential higher than that of plain nanofibers. Based on this study, the bioactive N6 nanofibers matrix treated with HA nanoplated is regarded as a promising next-generation biomaterial in the bone regeneration field. (c) 2014 Elsevier B.V. All rights reserved.
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页码:378 / 381
页数:4
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