SYNTHESIS OF SOME NEW N-SUBSTITUTED-9-METHYL-PYRROLO[3,4-B]QUINOLIN-1-ONES

被引：0

作者：

Wang, Yu ^{[1
]}

Li, Xingpeng ^{[1
]}

Wang, Yang ^{[1
]}

Fu, Xinbo ^{[1
]}

Li, Yang ^{[1
]}

Gao, Wentao ^{[1
]}

机构：

[1] Bohai Univ, Inst Superfine Chem, Jinzhou, Liaoning, Peoples R China

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 26卷 / 3-4期

关键词：

Quinoline; Amine; Pyrrolo[3,4-b]quinolin-l-one; Williamson-type reaction; intramolecular cyclization; synthesis; ONE-POT SYNTHESIS; DERIVATIVES; QUINOLINE; CYCLIZATION; INHIBITOR;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile one-pot protocol for the synthesis of a series of quinoline-based isoindolin-l-ones, namely N-substituted-9-methyl-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-l-ones 3a-m has been achieved via a two-step procedure, involving a cascade Williamson-type condensation reaction of ethyl 2-(chloromethyl)-4-methylquinoline-3-carboxylate (1) with various amines 2a-m and subsequent intramolecular C-N bond cyclizaiton of the resulting intermediates in refluxing EtOH-AcOH (V/V, 10:1) solvent system in a single synthetic operation. The structures of all the newly synthesized compounds were confirmed by spectral data and HRMS.

引用

页码：155 / 161

页数：7

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