Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus

被引：44
作者：
Baltch, Aldona L. [1 ]
Ritz, William J.
Bopp, Lawrence H.
Michelsen, Phyllis B.
Smith, Raymond P.
机构：
[1] Stratton VA Med Ctr, Infect Dis Sect 111D, Albany, NY 12208 USA
[2] Albany Med Coll, Albany, NY 12208 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期
关键词：
D O I：
10.1128/AAC.00973-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the anti staphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of daptomycin, gentamicin, and rifampin was most effective intracellularly, while daptomycin plus gentamicin and the three-drug combination were most effective extracellularly, completely eliminating viable Staphylocorcus aureus.
引用
收藏
页码：1559 / 1562
页数：4
相关论文
共 17 条
  • [1] Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages
    Barcia-Macay, M
    Seral, C
    Mingeot-Leclercq, MP
    Tulkens, PM
    Van Bambeke, F
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (03) : 841 - 851
  • [2] In vivo and in vitro demonstration that Staphylococcus aureus is an intracellular pathogen in the presence or absence of fibronectin-binding proteins
    Brouillette, E
    Grondin, G
    Shkreta, L
    Lacasse, P
    Talbot, BG
    [J]. MICROBIAL PATHOGENESIS, 2003, 35 (04) : 159 - 168
  • [3] Daptomycin in the Treatment of Persistent Bacteremia With Invasive Complications Caused by a Small Colony Variant of Methicillin-resistant Staphylococcus aureus in an Orthopedic Patient
    Carlyn, Cynthia J.
    Baltch, Aldona L.
    George, Mary J.
    Smith, Raymond P.
    [J]. INFECTIOUS DISEASES IN CLINICAL PRACTICE, 2006, 14 (06) : 394 - 398
  • [4] Intracellular pharmacodynamics of antibiotics
    Carryn, S
    Chanteux, H
    Seral, C
    Mingeot-Leclercq, MP
    Van Bambeke, F
    Tulkens, PM
    [J]. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2003, 17 (03) : 615 - +
  • [5] Cilli F, 2006, J CHEMOTHERAPY, V18, P27
  • [6] INTRACELLULAR SURVIVAL OF STAPHYLOCOCCI
    KAPRAL, FA
    SHAYEGANI, MG
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1959, 110 (01) : 123 - 138
  • [7] Comparative activity of the new lipoglycopeptide telavancin in the presence and absence of serum against 50 glycopeptide non-susceptible staphylococci and three vancomycin-resistant Staphylococcus aureus
    Leuthner, Kimberly D.
    Cheung, Chrissy M.
    Rybak, Michael J.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (02) : 338 - 343
  • [8] Antimicrobial tissue concentrations
    Liu, P
    Derendorf, H
    [J]. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2003, 17 (03) : 599 - +
  • [9] KILLING OF INTRALEUKOCYTIC STAPHYLOCOCCUS-AUREUS BY RIFAMPIN - IN-VITRO AND IN-VIVO STUDIES
    MANDELL, GL
    VEST, TK
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1972, 125 (05) : 486 - &
  • [10] Daptomycin structure and mechanism of action revealed
    Micklefield, J
    [J]. CHEMISTRY & BIOLOGY, 2004, 11 (07): : 887 - 888
12