A novel mutation in CD83 results in the development of a unique population of CD4+ T cells

被引：43

作者：

García-Martínez, LF ^{[1
]}

Appleby, MW ^{[1
]}

Staehling-Hampton, K ^{[1
]}

Andrews, DM ^{[1
]}

Chen, YC ^{[1
]}

McEuen, M ^{[1
]}

Tang, P ^{[1
]}

Rhinehart, RL ^{[1
]}

Proll, S ^{[1
]}

Paeper, B ^{[1
]}

Brunkow, ME ^{[1
]}

Grandea, AG ^{[1
]}

Howard, ED ^{[1
]}

Walker, DE ^{[1
]}

Charmley, P ^{[1
]}

Jonas, M ^{[1
]}

Shaw, S ^{[1
]}

Latham, JA ^{[1
]}

Ramsdell, F ^{[1
]}

机构：

[1] Celltech Res & Dev Ltd, Bothell, WA 98021 USA

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 173卷 / 05期

关键词：

D O I：

10.4049/jimmunol.173.5.2995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a mouse mutagenesis screen, we have identified CD83 as being critical for the development of CD4(+) T cells and for their function postactivation. CD11c(+) dendritic cells develop and function normally in mice with a mutated CD83 gene but CD4(+) T cell development is substantially reduced. Additionally, we now show that those CD4(+) cells that develop in a CD83 mutant animal fail to respond normally following allogeneic stimulation. This is at least in part due to an altered cytokine expression pattern characterized by an increased production of IL-4 and IL-10 and diminished IL-2 production. Thus, in addition to its role in selection of CD4(+) T cells, absence of CD83 results in the generation of cells with an altered activation and cytokine profile.

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收藏

页码：2995 / 3001

页数：7

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