Glycogen synthase kinase-3β -: Actively inhibiting hypertrophy

被引：42
|
作者：
Kerkela, Risto [1 ]
Woulfe, Kathleen [1 ]
Force, Thomas [1 ]
机构：
[1] Jefferson Med Coll, Ctr Translat Med, Philadelphia, PA 19107 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2007年 / 17卷 / 03期
关键词：
CARDIAC MYOCYTE HYPERTROPHY; PROTEIN-KINASE; IN-VIVO; CELL-GROWTH; CARDIOMYOCYTE HYPERTROPHY; DEPENDENT TRANSCRIPTION; SIGNALING PATHWAYS; BETA-CATENIN; COLON-CANCER; C-MYC;
D O I：
10.1016/j.tcm.2007.01.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inputs, and as a transducer to downstream effectors, is the protein kinase, glycogen synthase kinase-3 beta. In this work we review the role of this putative "nodal point" in the response of the heart to growth stimuli, both physiologic and pathologic.
引用
收藏
页码：91 / 96
页数：6
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