Translational Mini-Review Series on Th17 Cells: Are T helper 17 cells really pathogenic in autoimmunity?

被引：34
|
作者：
Koenders, M. I. [1 ]
van den Berg, W. B. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2010年 / 159卷 / 02期
关键词：
arthritis; autoimmunity; IL-17; Th17; cells; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; CARTILAGE DESTRUCTION; JOINT INFLAMMATION; INTERFERON-GAMMA; BONE EROSION; ENCEPHALOMYELITIS; IL-21; MICE; INTERLEUKIN-17;
D O I：
10.1111/j.1365-2249.2009.04039.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P>In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.
引用
收藏
页码：131 / 136
页数：6
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