Translational Mini-Review Series on Th17 Cells: Are T helper 17 cells really pathogenic in autoimmunity?

被引：34

作者：

Koenders, M. I. ^{[1
]}

van den Berg, W. B. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2010年 / 159卷 / 02期

关键词：

arthritis; autoimmunity; IL-17; Th17; cells; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; CARTILAGE DESTRUCTION; JOINT INFLAMMATION; INTERFERON-GAMMA; BONE EROSION; ENCEPHALOMYELITIS; IL-21; MICE; INTERLEUKIN-17;

D O I：

10.1111/j.1365-2249.2009.04039.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.

引用

页码：131 / 136

页数：6

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