Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

被引：10
作者：
Hauss, Frederique
Liu, Jiawei
Michelucci, Alessandro
Coowar, Djalil
Morga, Eleonora
Heuschling, Paul
Luu, Bang
机构：
[1] Univ Strasbourg 1, CNRS, UMR 7177, Lab Chim Organ Substances Nat, F-67084 Strasbourg, France
[2] Univ Luxembourg, Lab Neurobiol, Unite Rech Sci Vie, Fac Sci Technol & Commun, Luxembourg, Luxembourg
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 15期
关键词：
resveratrol fatty alcohols; neuroinflammation; neural stem cells; microglia; neurodegenerative diseases;
D O I：
10.1016/j.bmcl.2007.05.037
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4218 / 4222
页数：5
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