Room Temperature, Copper-Catalyzed Amination of Bromonaphthyridines with Aqueous Ammonia

被引：28

作者：

Anderson, Cyrus A. ^{[1
]}

Taylor, Phillip G. ^{[1
]}

Zeller, Mary A. ^{[1
]}

Zimmerman, Steven C. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 14期

关键词：

HYDROGEN-BONDED HETERODIMERS; ARYL HALIDES; MOLECULAR RECOGNITION; C-N; HETEROCYCLIC UREAS; POLYMERS; COMPLEXATION; EFFICIENT; MECHANISMS; SULFONATES;

D O I：

10.1021/jo100476x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu2O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.

引用

页码：4848 / 4851

页数：4

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