Room Temperature, Copper-Catalyzed Amination of Bromonaphthyridines with Aqueous Ammonia

被引：28
作者：
Anderson, Cyrus A. [1 ]
Taylor, Phillip G. [1 ]
Zeller, Mary A. [1 ]
Zimmerman, Steven C. [1 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 14期
关键词：
HYDROGEN-BONDED HETERODIMERS; ARYL HALIDES; MOLECULAR RECOGNITION; C-N; HETEROCYCLIC UREAS; POLYMERS; COMPLEXATION; EFFICIENT; MECHANISMS; SULFONATES;
D O I：
10.1021/jo100476x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Room temperature, copper-catalyzed amination of amido-bromo-1,8-naphthyridines is reported. Use of Cu2O and aqueous ammonia at ambient temperature affords amination products in 10-87% yield. Bromonaphthyridines are prepared in 15-65% yield via treatment of amidonaphthyridinones with phosphorus tribromide. This methodology provides an alternative route to functional, nonsymmetric 2,7-diamido-1,8-naphthyridines.
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收藏
页码：4848 / 4851
页数：4
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