Efficient Synthesis of Diarylmethylamines via Lewis Acid Catalyzed Friedel-Crafts Reactions of Donor-Acceptor Aziridines with N,N-Dialkylanilines

被引：5
|
作者：
Kim, Yerin [1 ]
Kwon, Yong Il [1 ]
Kim, Sung-Gon [1 ]
机构：
[1] Kyonggi Univ, Dept Chem, 154-42 Gwanggyosan Ro, Suwon 16227, South Korea
来源：
SYNTHESIS-STUTTGART | 2020年 / 52卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
diarylmethylamine; Friedel-Crafts reaction; donor-acceptor aziridine; N; N-dialkylaniline; Lewis acid; ASYMMETRIC 3+2 CYCLOADDITION; CHIRAL DIENE LIGANDS; H BOND ARYLATION; N-TOSYLAZIRIDINES; C-ARYLATION; N; N-DIALKYL-3-VINYLANILINES; DERIVATIVES; FUNCTIONALIZATION; TOSYLARYLIMINES; ALDEHYDES;
D O I：
10.1055/s-0039-1690731
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for efficient and mild synthesis of diarylmethylamine scaffold, via Lewis acid catalyzed Friedel-Crafts reaction of donor-acceptor aziridines with N,N-dialkylanilines to afford a biologically important diarylmethylamine derivatives in high yields (up to 88%), is presented. This reaction is suitable for the synthesis of various diarylmethylamine derivatives and has a broad scope for electron-rich arenes, including dimethoxybenzene.
引用
收藏
页码：281 / 289
页数：9
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