Synthesis and Antibacterial Activity of Some New Benzo[5,6] chromeno[2,3-d] pyrimidines

被引：12
作者：
Ameli, Shohreh [1 ]
Pordel, Mehdi [1 ]
Davoodnia, Abolghasem [1 ]
Jajarmi, Maryam [1 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Mashhad Branch, Mashhad 9187147578, Iran
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2017年 / 43卷 / 04期
关键词：
benzo[5,6] chromeno[2,3-d] pyrimidine; NOESY experiment; antibacterial activity; MIC; ANTIMICROBIAL ACTIVITIES; HETEROCYCLIC SYSTEM; DERIVATIVES; AGENTS; ANTIPLATELET;
D O I：
10.1134/S1068162017040100
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis and antibacterial activity of some new benzo[5,6]chromeno[2,3-d]pyrimidine derivatives are described. The title compounds were obtained by the reaction of 1H-benzo[f]chromenes with aliphatic and aromatic amines. The structures of all newly synthesized compounds were confirmed by IR, (HNMR)-H-1, C-13 NMR, and NOESY experiments. The compounds exhibited potent antibacterial activity against gram-positive and gram-negative bacterial species. 10-Methyl-12-(4-hydroxyphenyl)-10,12-dihydro-11H-benzo[5,6]chromeno[2,3-d] pyrimidin-11-imine displayed greater antibacterial activity against gramnegative bacterial species than did ciprofloxacinandamoxicillin.
引用
收藏
页码：429 / 434
页数：6
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