A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius

被引：5

作者：

Chen, De-Li ^{[1
,2
]}

Zhang, Xiao-Po ^{[3
]}

Ma, Guo-Xu ^{[4
,5
]}

Wu, Hai-Feng ^{[4
,5
]}

Yang, Jun-Shan ^{[4
,5
]}

Xu, Xu-Dong ^{[4
,5
]}

机构：

[1] Chinese Acad Med Sci, Hainan Prov Key Lab Resources Conservat & Dev Sou, Inst Med Plant Dev, Hainan Branch, Wanning 571533, Peoples R China

[2] Peking Union Med Coll, Wanning 571533, Peoples R China

[3] Hainan Med Univ, Sch Pharmaceut Sci, 3 Xueyuan Rd, Haikou 571101, Peoples R China

[4] Chinese Acad Med Sci, Inst Med Plant Dev, 151 Malianwa North Rd, Beijing 100193, Peoples R China

[5] Peking Union Med Coll, 151 Malianwa North Rd, Beijing 100193, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 05期

关键词：

Abelmoschus sagittifolius; sesquiterpenoid; cytotoxicity;

D O I：

10.1080/14786419.2015.1033624

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines.

引用

页码：565 / 569

页数：5

共 10 条

[1] Enantiodivergent synthesis of both enantiomers of the macrocyclic lactone lasiodiplodin
Bracher, F
Schulte, B
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (21): : 2619 - 2622
[2] Chen HY, 1965, FLORA OF HAINAN, V2
[3] Chinese Herbalism Editorial Board State Administration of Traditional Chinese Medicine of the People's Republic of China, 1999, CHINESE MAT MED
[4] Ferreira MA, 1980, J CHEM SOC PERK T, V1, P249, DOI [10.1039/p19800000249, DOI 10.1039/P19800000249]
[5] A new triterpenoid saponin from Ardisia gigantifolia
Mu, Li-Hua
Huang, Xiao-Wu
Guo, Dai-Hong
Dong, Xian-Zhe
Liu, Ping
[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 15 (10) : 1123 - 1129
[6] PHOTOLACTONIZATION - A NOVEL SYNTHETIC ENTRY TO MACROLIDES
QUINKERT, G
BILLHARDT, UM
JAKOB, H
FISCHER, G
GLENNEBERG, J
NAGLER, P
AUTZE, V
HEIM, N
WACKER, M
SCHWALBE, T
KURTH, Y
BATS, JW
DURNER, G
ZIMMERMANN, G
KESSLER, H
[J]. HELVETICA CHIMICA ACTA, 1987, 70 (03) : 771 - 861
[7] Wang YF, 2009, J ANHUI AGR SCI, V37, P11001
[8] A new periplogenin cardenolide from the seeds of Antiaris toxicaria
Wu, Xiu-Li
Wu, Yu-Ling
Li, Hou-Gang
Liu, He-Tao
Fu, Xue-Yan
Cui, Rui-Qin
Wang, Jian-Huan
Liu, Cheng
Chen, Jing
[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 16 (04) : 418 - 421
[9] [杨瑞云 YANG Ruiyun], 2007, [分析测试学报, Journal of Instrumental Analysis], V26, P12
[10] Ethnobotanical study on medicinal plants around Limu Mountains of Hainan Island, China
Zheng, Xi-long
Wei, Jian-he
Sun, Wei
Li, Rong-tao
Liu, Shou-bai
Dai, Hao-fu
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2013, 148 (03) : 964 - 974

← 1 →