Microbial genome analysis: Insights into virulence, host adaptation and evolution

被引：83

作者：

Wren, BW ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

NATURE REVIEWS GENETICS | 2000年 / 1卷 / 01期

关键词：

D O I：

10.1038/35049551

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genome analysis of microbial pathogens has provided unique insights into their virulence, I host adaptation and evolution. Common themes have emerged, including lateral gene transfer among enteric pathogens, genome decay among obligate intracellular pathogens and antigenic Variation among mucosal pathogens. The advent of post-genomic approaches and the sequencing of the human genome will enable scientists to investigate the complex I and dynamic interplay between host aod pathogen. This wealth of information will catalyse the development of new intervention strategies to reduce the burden of microbial-related disease.

引用

页码：30 / 39

页数：10

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