Iron-Catalyzed Intermolecular 1,2-Difunctionalization of Styrenes and Conjugated Alkenes with Silanes and Nucleophiles

被引：142

作者：

Yang, Yuan ^{[1
,2
]}

Song, Ren-Jie ^{[1
,2
]}

Ouyang, Xuan-Hui ^{[1
,2
]}

Wang, Cheng-Yong ^{[1
,2
]}

Li, Jin-Heng ^{[1
,2
]}

Luo, Shenglian ^{[1
,2
]}

机构：

[1] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China

[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 27期

关键词：

alkenes; iron; radicals; reaction mechanisms; silanes; INTRAMOLECULAR BIS-SILYLATION; ALPHA-AMINO-ACIDS; STEREOSELECTIVE-SYNTHESIS; DEHYDROGENATIVE SILYLATION; REUPTAKE INHIBITOR; TERTIARY SILANES; RECENT PROGRESS; HYDROSILYLATION; SILICON; ACTIVATION;

D O I：

10.1002/anie.201702349

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first iron-catalyzed 1,2-difunctionalization of styrenes and conjugated alkenes with silanes and either N or C, using an oxidative radical strategy, is described. Employing FeCl2 and di-tert-butyl peroxide allows divergent alkene 1,2-difunctionalizations, including 1,2-aminosilylation, 1,2-arylsilylation, and 1,2-alkylsilylation, which rely on a wide range of nucleophiles, namely, amines, amides, indoles, pyrroles, and 1,3-dicarbonyls, thus providing a powerful platform for producing diverse silicon-containing alkanes.

引用

页码：7916 / 7919

页数：4

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