Host-directed therapies for COVID-19

被引：9

作者：

Maeurer, Markus ^{[1
,2
]}

Ramalho, Renata ^{[3
]}

Wang, Fu-Sheng ^{[4
]}

Zumla, Alimuddin ^{[5
,6
]}

机构：

[1] Champalimaud Ctr Unknown, ImmunoSurg Unit, Lisbon, Portugal

[2] Johannes Gutenberg Univ Mainz, Med Klin 1, Mainz, Germany

[3] Inst Univ Egas Moniz, Ctr Invest Interdisciplinar Egas Moniz CiiEM, Appl Nutr Studies Grp GENA IUEM, Egas Moniz Higher Educ Sch,FCT,U4585, Monte De Caparica, Portugal

[4] Peoples Liberat Army Gen Hosp, Med Ctr 5, Natl Clin Res Ctr Infect Dis, Treatment & Res Ctr Infect Dis, Beijing, Peoples R China

[5] UCL, Div Infect & Immun, Dept Infect, London, England

[6] Univ Coll London Hosp NHS Fdn Trust, Natl Inst Hlth & Res, Biomed Res Ctr, London, England

来源：

CURRENT OPINION IN PULMONARY MEDICINE | 2021年 / 27卷 / 03期

基金：

欧盟地平线“2020”; 美国国家卫生研究院;

关键词：

COVID-19; host-directed therapies; interleukins; mesenchymal stem cells; severe acute respiratory syndrome coronavirus-2; REDUCING MORTALITY; DISEASE; TOCILIZUMAB; OUTCOMES;

D O I：

10.1097/MCP.0000000000000769

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Purpose of review Severe acute respiratory syndrome coronavirus-2-induced hyperinflammation is a major cause of death or end-organ dysfunction in COVID-19 patients. We review adjunct host-directed therapies (HDTs) for COVID-19 management. Recent findings The use of umbilical cord-derived mesenchymal stem cells as HDT for COVID-19 has been shown to be safe in phase 1 and 2 trials. Trials of anti-interleukin-6 receptor antibodies show promising mortality benefit in hospitalized COVID-19 patients. Repurposed drugs and monoclonal antibodies targeting specific cytokines acting on different aspects of the pro- and anti-inflammatory cascades are under evaluation. A range of HDTs shows promise for reducing mortality and improving long term disability in patients with severe COVID-19, and require evaluation in randomized, controlled trials

引用

页码：205 / 209

页数：5

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