Fibrosis of Peritoneal Membrane as Target of New Therapies in Peritoneal Dialysis

被引：46

作者：

Masola, Valentina ^{[1
]}

Bonomini, Mario ^{[2
]}

Borrelli, Silvio ^{[3
]}

Di Liberato, Lorenzo ^{[2
]}

Vecchi, Luigi ^{[4
]}

Onisto, Maurizio ^{[1
]}

Gambaro, Giovanni ^{[5
]}

Palumbo, Roberto ^{[6
]}

Arduini, Arduino ^{[7
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy

[2] Univ G dAnnunzio, Sect Nephrol & Dialysis, Dept Med, I-66013 Chieti, Italy

[3] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Unit Nephrol, I-80138 Naples, Italy

[4] Santa Maria Hosp, Unit Nephrol, Terni, Italy

[5] Dept Med, Div Nephrol & Dialysis, Piazzale A Stefani 1, I-37126 Verona, Italy

[6] St Eugenio Hosp, Unit Nephrol, I-00144 Rome, Italy

[7] Iperboreal Pharma, R&D Dept, I-65122 Pescara, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 09期

关键词：

peritoneal dialysis; biocompatibility; fibrosis; TISSUE GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; SOLUTE TRANSPORT RATE; PROTEIN-KINASE-C; QUALITY-OF-LIFE; TGF-BETA SIGNAL; NF-KAPPA-B; MESOTHELIAL CELLS; GENE-TRANSFER; RENAL-DISEASE;

D O I：

10.3390/ijms23094831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peritoneal dialysis (PD) is an efficient renal replacement therapy for patients with end-stage renal disease. Even if it ensures an outcome equivalent to hemodialysis and a better quality of life, in the long-term, PD is associated with the development of peritoneal fibrosis and the consequents patient morbidity and PD technique failure. This unfavorable effect is mostly due to the bio-incompatibility of PD solution (mainly based on high glucose concentration). In the present review, we described the mechanisms and the signaling pathway that governs peritoneal fibrosis, epithelial to mesenchymal transition of mesothelial cells, and angiogenesis. Lastly, we summarize the present and future strategies for developing more biocompatible PD solutions.

引用

页数：19

共 185 条

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