CD4+ Tregs and immune control

被引：330
作者：
Fehérvari, Z
Sakaguchi, S
机构：
[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan
[2] RIKEN, Inst Phys & Chem Res, Immunopathol Lab, Res Ctr Allergy & Immunol, Yokohama, Kanagawa, Japan
[3] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Japan
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 09期
关键词：
D O I：
10.1172/JCI200434495
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent years have seen Tregs become a popular subject of immunological research. Abundant experimental data have now confirmed that naturally occurring CD25(+)CD4(+) Tregs in particular play a key role in the maintenance of self tolerance, with their dysfunction leading to severe or even fatal immunopathology. The sphere of influence of Tregs is now known to extend well beyond just the maintenance of immunological tolerance and to impinge on a host of clinically important areas from cancer to infectious diseases. The identification of specific molecular markers in both human and murine immune systems has enabled the unprecedented investigation of these cells and should prove key to ultimately unlocking their clinical potential.
引用
收藏
页码：1209 / 1217
页数：9
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