Determination of anti-inflammatory drugs and estrogens in water by HPLC with UV detection

被引：113

作者：

Stafiej, Anna

Pyrzynska, Krystyna

Regan, Fiona

机构：

[1] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

[2] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

来源：

JOURNAL OF SEPARATION SCIENCE | 2007年 / 30卷 / 07期

关键词：

acidic drugs; estrogens; water analysis;

D O I：

10.1002/jssc.200600433

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An analytical method based on LC and UV detection has been developed for the determination of anti-inflammatory compounds and estrogens in water samples. The drugs investigated were diclofenac, ketoprofen, ibuprofen, naproxen, clofibric acid, estriol, 17 beta-estradiol, estrone and ethynylestradiol. The detection limits were in the range of 6-74 mu g/L and 0.041-0.16 mg/L for acidic pharmaceuticals and estrogens, respectively, using narrow-bore C18 analytical column. Analyte enrichment from water samples was achieved by SPE procedure using polymeric Strata-X cartridges. Average recoveries obtained from 2.5 L of surface water sample were in the range of 77-98%.

引用

页码：985 / 991

页数：7

共 20 条

[1] Determination of drug residues in water by the combination of liquid chromatography or capillary electrophoresis with electrospray mass spectrometry
Ahrer, W
Scherwenk, E
Buchberger, W
[J]. JOURNAL OF CHROMATOGRAPHY A, 2001, 910 (01) : 69 - 78
[2] Liquid chromatography-tandem mass spectrometry analysis of estrogenic compounds in coastal surface water of the Baltic Sea
Beck, IC
Bruhn, R
Gandrass, J
Ruck, W
[J]. JOURNAL OF CHROMATOGRAPHY A, 2005, 1090 (1-2) : 98 - 106
[3] Pharmaceuticals and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) in stormwater canals and Bayou St. John in New Orleans, Louisiana, USA
Boyd, GR
Palmeri, JM
Zhang, SY
Grimm, DA
[J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2004, 333 (1-3) : 137 - 148
[4] Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry:: methods and preliminary results including toxicity studies with Vibrio fischeri
Farré, ML
Ferrer, I
Ginebreda, A
Figueras, M
Olivella, L
Tirapu, L
Vilanova, M
Barceló, D
[J]. JOURNAL OF CHROMATOGRAPHY A, 2001, 938 (1-2) : 187 - 197
[5] Determination of clofibric acid and N-(phenylsulfonyl)-sarcosine in sewage, river and drinking water
Heberer, T
Stan, HJ
[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, 1997, 67 (1-4) : 113 - 123
[6] Comparative study of analytical methods involving gas chromatography-mass spectrometry after derivatization and gas chromatography-tandem mass spectrometry for the determination of selected endocrine disrupting compounds in wastewaters
Hernando, MD
Mezcua, M
Gómez, MJ
Malato, O
Agüera, A
Fernández-Alba, AR
[J]. JOURNAL OF CHROMATOGRAPHY A, 2004, 1047 (01) : 129 - 135
[7] Improved method for analyzing estrogens in water by liquid chromatography-electrospray mass spectrometry
Hu, JY
Zhang, HF
Chang, H
[J]. JOURNAL OF CHROMATOGRAPHY A, 2005, 1070 (1-2) : 221 - 224
[8] Analysis of steroid hormones in effluents of wastewater treatment plants by liquid chromatography-tandem mass spectrometry
Ingrand, V
Herry, G
Beausse, J
de Roubin, MR
[J]. JOURNAL OF CHROMATOGRAPHY A, 2003, 1020 (01) : 99 - 104
[9] Determination of non-steroidal anti-inflammatory drugs in surface water and wastewater by liquid chromatography-tandem mass spectrometry
Marchese, S
Perret, D
Gentili, A
Curini, R
Pastori, F
[J]. CHROMATOGRAPHIA, 2003, 58 (5-6) : 263 - 269
[10] Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry
Miao, XS
Koenig, BG
Metcalfe, CD
[J]. JOURNAL OF CHROMATOGRAPHY A, 2002, 952 (1-2) : 139 - 147

← 1 2 →