Chemotherapy-induced parkinsonism responsive to levodopa: An underrecognized entity

被引:16
作者
Chuang, C
Constantino, A
Balmaceda, C
Eidelberg, D
Frucht, SJ
机构
[1] Columbia Presbyterian Med Ctr, Inst Neurol, New York, NY USA
[2] N Shore Univ Hosp, Manhasset, NY USA
关键词
parkinsonism; chemotherapy; levodopa;
D O I
10.1002/mds.10344
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Parkinsonism is a rare neurological complication of cancer treatment. Although individual case reports of this syndrome have been reported, the clinical features and prevalence of this syndrome are unknown. We present 3 patients, encountered over 6 months at one institution, who developed parkinsonism after treatment with various chemotherapeutic agents. Parkinsonism was severe in 2 patients, affecting postural reflexes, speech, and swallowing. All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months. This unusual complication of cancer therapy is treatable and may be underappreciated. (C) 2002 Movement Disorder Society.
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页码:328 / 331
页数:4
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