Identification, expression and tissue distribution of cytidine 5′-monophosphate N-acetylneuraminic acid synthetase activity in the rat

被引：8

作者：

Revilla-Nuin, B ^{[1
]}

Reglero, A ^{[1
]}

Feo, JC ^{[1
]}

Rodriguez-Aparicio, LB ^{[1
]}

Ferrero, MA ^{[1
]}

机构：

[1] Univ Leon, Dept Bioquim & Biol Mol, E-24007 Leon, Spain

来源：

GLYCOCONJUGATE JOURNAL | 1998年 / 15卷 / 03期

关键词：

N-acetylneuraminic acid cytidylyltransferase; rat;

D O I：

10.1023/A:1006940927639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the postnatal developmental profiles of N-acetylneuraminic acid cytidylyltransferase (EC 2.7.7.43) (CMP-Neu5Ac synthetase) in different rat tissues. This enzyme, which catalyses the activation of NeuAc to CMP-Neu5Ac, was detected in brain, kidney, heart, spleen, liver, stomach, intestine, lung, thymus, prostate and urinary bladder but not in skeletal muscle. Comparative analysis of the different specific activity profiles obtained shows that the expression of CMP Neu5Ac synthetase is tissue-dependent and does not seem to be embryologically determined. Changes in the level of sialylation during development were also found to be intimately related to variations in the expression of this enzyme, at least in brain, heart, kidney, stomach, intestine and lung.

引用

页码：233 / 241

页数：9

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