Placental apoptosis in recurrent miscarriage

被引:30
作者
Atia, Tarek A. [1 ]
机构
[1] Prince Sattam Bin Abdul Aziz Univ, Coll Appl Med Sci, Histol & Cell Biol, POB 422, Riyadh 11942, Saudi Arabia
关键词
Apoptosis; Immuno-histochemistry; Placenta; RM; EXPRESSION; VILLI; MACROPHAGES; TROPHOBLAST; TRIMESTER; 1ST; BAX; P53;
D O I
10.1016/j.kjms.2017.06.012
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM). Placental tissue samples were collected from 40 women with RM (study group) and 30 women with sporadic spontaneous abortion (control group). Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53) and antiapoptotic Bcl-2 antibodies. Our results showed that expression of the apoptotic (p53) protein was significantly increased in the placental tissues of the RM group (p = 0.003). By contrast, the expression of anti-apoptotic (Bcl-2) antibodies was significantly increased in the placental tissues of the control group (p = 0.025). We concluded that placental apoptosis plays a crucial role in pregnancy continuation. However, increased p53 expression in placental tissue in early pregnancy could negatively affect pregnancy continuation. Copyright (C) 2017, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
引用
收藏
页码:449 / 452
页数:4
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