Carotid intima-media thickness is not associated with vitamin D and PTH levels in patients admitted to an Internal Medicine Department

被引：14

作者：

Carnevale, Vincenzo ^{[1
]}

Minonne, Rita ^{[1
]}

De Matthaeis, Angela ^{[1
]}

Annese, Maria Antonietta ^{[1
]}

Tabacco, Patrizia ^{[2
]}

D'Arcangelo, Palmina ^{[3
]}

D'Amico, Graziella ^{[1
]}

Scillitani, Alfredo ^{[4
]}

机构：

[1] IRCCS, Unit Internal Med, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy

[2] IRCCS, Nucl Med Unit, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy

[3] IRCCS, Unit Clin Chem, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy

[4] IRCCS, Unit Endocrinol, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy

来源：

ENDOCRINE | 2014年 / 47卷 / 03期

关键词：

Intima-media thickness; Vitamin D; PTH; PTH/vitamin D ratio; Inpatients; PARATHYROID-HORMONE; CARDIOVASCULAR-DISEASE; 25-HYDROXYVITAMIN D; GENERAL-POPULATION; METABOLIC SYNDROME; HEALTHY-SUBJECTS; D DEFICIENCY; ALL-CAUSE; ATHEROSCLEROSIS; EVENTS;

D O I：

10.1007/s12020-014-0191-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D (25OHD) and/or parathyroid hormone (PTH) levels have been associated with common carotid intima-media thickness (IMT). We investigated such associations in inpatients consecutively admitted to an Internal Medicine Department. In 168 consecutive patients admitted to our department, 25 hydroxyvitamin D (25OHD) was measured by means of RIA and PTH by means of ICMA, whereas IMT by means of ultrasonography. The main cardiovascular risk factors were also explored. In patients with either diabetes, or hypertension, or both, 25OHD values were not significantly lower than in other patients. No difference was found among the IMT values across tertiles of 25OHD level, as like as in the 25OHD, PTH, PTH/25OHD ratio values of patients either grouped by tertiles of IMT, or categorized according to IMT of < 0.9, 0.9-1.5, and > 1.5 mm. IMT did not significantly associate with 25OHD, PTH, and PTH/25OHD ratio, whereas it positively associated with age (r = 0.281; p < 0.001) and BMI (r = 0.138; p = 0.074), and negatively with eGFR (r = -154; p = 0.046). Multiple regression models showed that IMT was significantly associated to age and BMI, while 25OHD, PTH, or PTH/25OHD ratio did not increase the significance of the models. IMT assessment does not seem to be associated with 25OHD and PTH levels in unselected inpatients.

引用

页码：833 / 838

页数：6

共 30 条

[1] 25-Hydroxyvitamin D and Parathyroid Hormone Are Not Associated With Carotid Intima-Media Thickness or Plaque in the Multi-Ethnic Study of Atherosclerosis [J].