Carotid intima-media thickness is not associated with vitamin D and PTH levels in patients admitted to an Internal Medicine Department

被引:13
作者
Carnevale, Vincenzo [1 ]
Minonne, Rita [1 ]
De Matthaeis, Angela [1 ]
Annese, Maria Antonietta [1 ]
Tabacco, Patrizia [2 ]
D'Arcangelo, Palmina [3 ]
D'Amico, Graziella [1 ]
Scillitani, Alfredo [4 ]
机构
[1] IRCCS, Unit Internal Med, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy
[2] IRCCS, Nucl Med Unit, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy
[3] IRCCS, Unit Clin Chem, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy
[4] IRCCS, Unit Endocrinol, Casa Sollievo della Sofferenza Hosp, I-71013 San Giovanni Rotondo, FG, Italy
关键词
Intima-media thickness; Vitamin D; PTH; PTH/vitamin D ratio; Inpatients; PARATHYROID-HORMONE; CARDIOVASCULAR-DISEASE; 25-HYDROXYVITAMIN D; GENERAL-POPULATION; METABOLIC SYNDROME; HEALTHY-SUBJECTS; D DEFICIENCY; ALL-CAUSE; ATHEROSCLEROSIS; EVENTS;
D O I
10.1007/s12020-014-0191-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vitamin D (25OHD) and/or parathyroid hormone (PTH) levels have been associated with common carotid intima-media thickness (IMT). We investigated such associations in inpatients consecutively admitted to an Internal Medicine Department. In 168 consecutive patients admitted to our department, 25 hydroxyvitamin D (25OHD) was measured by means of RIA and PTH by means of ICMA, whereas IMT by means of ultrasonography. The main cardiovascular risk factors were also explored. In patients with either diabetes, or hypertension, or both, 25OHD values were not significantly lower than in other patients. No difference was found among the IMT values across tertiles of 25OHD level, as like as in the 25OHD, PTH, PTH/25OHD ratio values of patients either grouped by tertiles of IMT, or categorized according to IMT of < 0.9, 0.9-1.5, and > 1.5 mm. IMT did not significantly associate with 25OHD, PTH, and PTH/25OHD ratio, whereas it positively associated with age (r = 0.281; p < 0.001) and BMI (r = 0.138; p = 0.074), and negatively with eGFR (r = -154; p = 0.046). Multiple regression models showed that IMT was significantly associated to age and BMI, while 25OHD, PTH, or PTH/25OHD ratio did not increase the significance of the models. IMT assessment does not seem to be associated with 25OHD and PTH levels in unselected inpatients.
引用
收藏
页码:833 / 838
页数:6
相关论文
共 30 条
  • [1] 25-Hydroxyvitamin D and Parathyroid Hormone Are Not Associated With Carotid Intima-Media Thickness or Plaque in the Multi-Ethnic Study of Atherosclerosis
    Blondon, Marc
    Sachs, Michael
    Hoofnagle, Andrew N.
    Ix, Joachim H.
    Michos, Erin D.
    Korcarz, Claudia
    Gepner, Adam D.
    Siscovick, David S.
    Kaufman, Joel D.
    Stein, James H.
    Kestenbaum, Bryan
    de Boer, Ian H.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (11) : 2639 - 2645
  • [2] Longitudinal evaluation of vitamin D status in healthy subjects from Southern Italy: Seasonal and gender differences
    Carnevale, V
    Modoni, S
    Pileri, M
    Di Giorgio, A
    Chiodini, I
    Minisola, S
    Vieth, R
    Scillitani, A
    [J]. OSTEOPOROSIS INTERNATIONAL, 2001, 12 (12) : 1026 - 1030
  • [3] Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: A study in a large cohort of healthy subjects
    Carnevale, Vincenzo
    Nieddu, Luciano
    Romagnoli, Elisabetta
    Battista, Claudia
    Mascia, Maria Lucia
    Chiodini, Iacopo
    Eller-Vainicher, Cristina
    Frusciante, Vincenzo
    Santini, Stefano Angelo
    La Porta, Michele
    Minisola, Salvatore
    Scillitani, Alfredo
    [J]. BONE, 2010, 47 (03) : 626 - 630
  • [4] Serum parathyroid hormone is associated with carotid intima-media thickness in postmenopausal women
    Choi, H. S.
    Kim, S. H.
    Rhee, Y.
    Cho, M. A.
    Lee, E. J.
    Lim, S. -K.
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2008, 62 (09) : 1352 - 1357
  • [5] Hypovitaminosis D in internal medicine inpatients
    Corino, A.
    D'Amelio, P.
    Gancia, R.
    Del Rizzo, P.
    Gabasio, S.
    Limone, P.
    Isaia, G.
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2007, 80 (02) : 76 - 80
  • [6] Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis
    de Groot, Eric
    van Leuven, Sander I.
    Duivenvoorden, Raphael
    Meuwese, Marijn C.
    Akdim, Fatima
    Bots, Michiel L.
    Kastelein, John Jp
    [J]. NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2008, 5 (05): : 280 - 288
  • [7] B-mode ultrasonographic characterization of carotid atherosclerotic plaques in symptomatic and asymptomatic patients
    Grogan, JK
    Shaalan, WE
    Cheng, HW
    Gewertz, B
    Desai, T
    Schwarze, G
    Glagov, S
    Lozanski, L
    Griffin, A
    Castilla, M
    Bassiouny, HS
    [J]. JOURNAL OF VASCULAR SURGERY, 2005, 42 (03) : 435 - 441
  • [8] The presence of a calcific plaque in the common carotid artery as a predictor of coronary atherosclerosis
    Kanadasi, Mehmet
    Cayli, Murat
    San, Mustafa
    Aikimbaev, Kairgeldy
    Alhan, C. Cumhur
    Demir, Mesut
    Demirtas, Mustafa
    [J]. ANGIOLOGY, 2006, 57 (05) : 585 - 592
  • [9] Low Dietary Vitamin D Predicts 34-Year Incident Stroke The Honolulu Heart Program
    Kojima, Gotaro
    Bell, Christina
    Abbott, Robert D.
    Launer, Lenore
    Chen, Randi
    Motonaga, Heather
    Ross, G. Webster
    Curb, J. David
    Masaki, Kamal
    [J]. STROKE, 2012, 43 (08) : 2163 - 2167
  • [10] Vitamin D: Epidemiology of cardiovascular risks and events
    Leu, Monica
    Giovannucci, Edward
    [J]. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 25 (04) : 633 - 646