Monoclonal Antibody MG7 as a Screening Tool for Gastric Cancer

被引：6

作者：

Chen, Zheng ^{[1
,2
]}

Hong, Liu ^{[1
,2
]}

Liu, Lin ^{[1
,2
]}

Peng, Daorong ^{[3
]}

Li, Quanjiang ^{[1
,2
]}

Jin, Bin ^{[1
,2
]}

Qiao, Taidong ^{[1
,2
]}

Wu, Kaichun ^{[1
,2
]}

Fan, Daiming ^{[1
,2
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Prov, Peoples R China

[2] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi Prov, Peoples R China

[3] Fourth Mil Med Univ, Dept Clin Lab, Xijing Hosp, Xian 710032, Shaanxi Prov, Peoples R China

来源：

HYBRIDOMA | 2010年 / 29卷 / 01期

关键词：

IMMUNO-PCR; ANTIGENS; ZINC-RIBBON-DOMAIN-CONTAINING-1; MUCOSA; CELLS;

D O I：

10.1089/hyb.2009.0067

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

MG7 is a gastric cancer-specific MAb with high specificity and sensitivity. By using MG7 MAb, we found that MG7Ag was increasingly detected in superficial gastritis, atrophic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer, indicating that MG7Ag could be considered an important early warning molecule of gastric cancer and MG7 MAb could be used as a tool for screening gastric cancer. We have developed a new and sensitive system, immuno-realtime PCR, for detection of MG7Ag in the serum. The use of qIPCR assays enabled the detection of MG7Ag in complex biological samples that were poorly accessible by conventional immunoassays.

引用

页码：27 / 30

页数：4

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