Pioglitazone improves superoxide dismutase mediated vascular reactivity in the obese Zucker rat

被引：10

作者：

Dorafshar, Amir H. ^{[3
,4
,5
]}

Moodley, Kogie ^{[3
]}

Khoe, Michelle ^{[3
]}

Lyon, Chris ^{[3
]}

Bryer-Ash, Michael ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Sch Med, Dept Med, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Sch Med, Harold Hamm Diabet Ctr, Oklahoma City, OK 73104 USA

[3] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Gonda Goldschmied Vasc Ctr, Los Angeles, CA 90024 USA

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2010年 / 7卷 / 01期

关键词：

thiazolidinedione; aorta; acetylcholine; insulin; obesity; ACTIVATED RECEPTOR-GAMMA; INSULIN-SENSITIZING AGENT; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE; ANTIDIABETIC AGENT; OXIDATIVE STRESS; CLINICAL-TRIAL; CELL-GROWTH; IN-VIVO; RESISTANCE;

D O I：

10.1177/1479164109341688

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To test the hypothesis that the thiazolidinedione agent, pioglitazone, mediates its chronic BP lowering action via improving vascular reactivity. Methods and Results: Lean (Fa/fa) and obese (fa/fa) Zucker rats were treated with or without pioglitazone (20 mg/kg/day) for 4 weeks (n=8 animals per group). Pioglitazone treatment was associated with a significant improvement in oral glucose tolerance in the obese animals (p<0.05 compared with untreated obese). Pioglitazone prevented the development of hypertension seen in obese untreated rats (SBP 126 +/- 1 versus 138 +/- 1 mmHg; p<0.0001). Aortic ring preparations from pioglitazone-treated obese rats showed improved relaxation responsiveness (ED50 0.28 versus 1.15 U/ml, p<0.001) to SOD, a NO potentiator, compared with untreated obese animals. Conclusions: SOD-mediated vasorelaxation may contribute to the chronic antihypertensive effect and/or the improvement in insulin sensitivity following pioglitazone treatment.

引用

页码：20 / 27

页数：8

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