Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor

被引：33

作者：

Zhi, Kang-Kang ^{[1
]}

Yang, Zhong-Duo ^{[1
]}

Shi, Dan-Feng ^{[2
]}

Yao, Xiao-Jun ^{[2
]}

Wang, Ming-Gang ^{[1
]}

机构：

[1] Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China

[2] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

来源：

FITOTERAPIA | 2014年 / 98卷

基金：

中国国家自然科学基金;

关键词：

Monoamine oxidase inhibitors; Desmodium elegans; Alkaloids; Monoamine oxidase;

D O I：

10.1016/j.fitote.2014.07.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Desmodeleganine (1), a new potential monoamine oxidase inhibitor, along with three known alkaloids, bufotenin (2), hydroxy-N, N-dimethyltryptamine N-12-oxide (3), 2-(5-methoxy-1H-indol-3-yl)-N, and N-dimethylethylamine (4) were isolated from the leaves of Desmodium elegans. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. 1 showed strong monoamine oxidase inhibitory activity with IC50 value of 13.92 +/- 1.5 mu M, when the IC50 value of iproniazid as a standard was 6.5 +/- 0.5 mu M. The molecular modeling was also performed to explore the binding mode of compounds 1, 2 at the active site of MAO-A and MAO-B. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：160 / 165

页数：6

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