Roles of inflammation in the natural history of intracranial saccular aneurysms

被引:20
作者
Wang, Jienan [1 ]
Wei, Liming [1 ]
Lu, Haitao [1 ]
Zhu, Yueqi [1 ]
机构
[1] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China
关键词
Inflammatory reaction; Intracranial aneurysm; Natural history; Intervention; HUMAN CEREBRAL ANEURYSMS; ANGIOTENSIN-CONVERTING ENZYME; FERUMOXYTOL-ENHANCED MRI; DEGENERATIVE CHANGES; ESTROGEN-RECEPTOR; GENE-EXPRESSION; NITRIC-OXIDE; TNF-ALPHA; SUBARACHNOID HEMORRHAGE; PHENOTYPIC MODULATION;
D O I
10.1016/j.jns.2020.117294
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aneurysmal subarachnoid hemorrhage is caused by intracranial aneurysm (IA) rupture and results in high rates of mortality and morbidity. Factors contributing to IA generation, growth and rupture can involve genetics, injury, hemodynamics, environmental factors, and inflammation, in which inflammatory factors are believed to play central roles in the whole natural history. Inflammatory reactions that contribute to IA development may involve synthesis of many functional proteins and expression of genes induced by changes of blood flow, external stimuli such as smoking, internal balance such as hormonal status changes, and blood pressure. Meanwhile, inflammatory reactions itself can evoke inflammatory cytokines release and aggregation such as MMPs, MCP-1, TNF-alpha and ZO-1, directly or indirectly promoting aneurysm growth and rupture. However, the details of these inflammatory reactions and their action on inflammatory chemokines are still unknown. Moreover, some agents with the function of anti-inflammation, lipid-lowering, antihypertension or inflammatory factor inhibition may have the potential benefit to reduce the risk of aneurysm development or rupture in a group of population despite the underlying mechanism remains unclear. Consequently, we reviewed the potential inflammatory responses and their mechanisms contributing to aneurysm development and rupture and sought intervention targets that may prevent IA rupture or generation.
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页数:12
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