Dietary exposure of acrylamide from the fifth Chinese Total Diet Study

被引：53

作者：

Gao, Jie ^{[1
,2
]}

Zhao, Yunfeng ^{[1
,2
]}

Zhu, Feng ^{[3
]}

Ma, Yongjian ^{[3
]}

Li, Xiaowei ^{[1
,2
]}

Miao, Hong ^{[1
,2
]}

Wu, Yongning ^{[1
,2
]}

机构：

[1] Minist Hlth, Key Lab Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, Peoples R China

[2] China Natl Ctr Food Safety Risk Assessment, 7 Panjiayuannanli, Beijing 100021, Peoples R China

[3] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2016年 / 87卷

关键词：

Acrylamide; Dietary exposure; Risk assessment; Total Diet Study; China; FOODS; POPULATION;

D O I：

10.1016/j.fct.2015.11.013

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The levels of acrylamide in 240 food composite samples from the 5th Chinese Total Diet Study (TDS) were measured using an LC-MS/MS method and the exposure estimates for the general population were evaluated. The samples were collected from 20 provinces in China, covering about two thirds of the Chinese population. Acrylamide was detected in 40.0% of composite samples with the concentrations ranged from 0.8 to 211.8 mu g/kg. The average dietary intakes from the 5th Chinese TDS were 0319 mu g kg(-1) bw day(-1) and an increase with about 70% was observed from the 3rd Chinese TDS in 2000 to the 5th Chinese TDS between 2009 and 2012. The main food group contributors to acrylamide exposure were vegetables (35.2%), cereals (34.3%) and potatoes (15.7%). Based on the benchmark dose lower confidence limit at 10% risk (BMDL10) of 0.31 mg kg(-1) bw day(-1) for the induction of mammary tumors in rats and 0.18 mg kg(-1) bw day(-1) for Harderian gland tumors in mice, the margins of exposure (MOEs) were 973 and 565 for Chinese general population, respectively. These MOEs indicate a human health concern. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：97 / 102

页数：6

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