Genomics of Cardiovascular Disease

被引：9
作者：
Manace, Leslie Cole [1 ]
Godiwala, Tapan N. [2 ]
Babyatsky, Mark W. [2 ]
机构：
[1] Kaiser Oakland Med Ctr, Dept Genet, Oakland, CA USA
[2] Mt Sinai Sch Med, Dept Med, New York, NY USA
来源：
MOUNT SINAI JOURNAL OF MEDICINE | 2009年 / 76卷 / 06期
关键词：
cardiology; genomics; pharmacogenetics; CORONARY-ARTERY-DISEASE; ATRIAL-FIBRILLATION; GENETIC-VARIATION; GENOMEWIDE ASSOCIATION; RANDOMIZED-TRIAL; STENT THROMBOSIS; CHROMOSOME; 4Q25; RISK; CLOPIDOGREL; POLYMORPHISM;
D O I：
10.1002/msj.20151
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
As the leading cause of death worldwide and a major cause of disability, cardiovascular disease remains a central focus of basic pharmacological treatment, Surgical interventions, and long-term care. Inherited, monogenic syndromes have provided insight into pathophysiological mechanisms across die range of cardiovascular diseases. with the advent Of post-Human Genome Project resources and technology, there has been a flood of research aimed at genome-wide predisposition markers pharmacogenetics, and genomic signatures in c complex Cardiovascular disorders. Genomic research has both further elucidated the impact of genes previous,sly identified in cardiovascular disease development and progression and discovered genomic regions as yet unknown to be associated with cardiovascular outcomes. The promise of personalized medicine lies in combining this genetic information with other biomarkers to tailor preventive and therapeutic strategies to individual patients for effective management, fewer adverse events, and preventive care. Mt Sinai J Med 76:613-623, 2009. (C) 2009 Mount Sinai School of Medicine
引用
收藏
页码：613 / U4
页数：11
相关论文
共 41 条
  • [21] Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation
    Kaab, Stefan
    Darbar, Dawood
    van Noord, Charlotte
    Dupuis, Josee
    Pfeufer, Arne
    Newton-Cheh, Christopher
    Schnabel, Renate
    Makino, Seiko
    Sinner, Moritz F.
    Kannankeril, Prince J.
    Beckmann, Britt M.
    Choudry, Subbarao
    Donahue, Brian S.
    Heeringa, Jan
    Perz, Siegfried
    Lunetta, Kathryn L.
    Larson, Martin G.
    Levy, Daniel
    MacRae, Calum A.
    Ruskin, Jeremy N.
    Wacker, Annette
    Schoemig, Albert
    Wichmann, H.-Erich
    Steinbeck, Gerhard
    Meitinger, Thomas
    Uitterlinden, Andre G.
    Witteman, Jacqueline C. M.
    Roden, Dan M.
    Benjamin, Emelia J.
    Ellinor, Patrick T.
    [J]. EUROPEAN HEART JOURNAL, 2009, 30 (07) : 813 - 819
  • [22] Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Kathiresan, Sekar
    Altschuler, David
    Anand, Sonia
    Ardissino, Diego
    Asselta, Rosanna
    Ball, Stephen G.
    Balmforth, Anthony J.
    Berger, Klaus
    Berglund, Goran
    Bernardi, Francesco
    Bernardinelli, Luisa
    Berzuini, Carlo
    Braund, Peter S.
    Burnett, Mary-Susan
    Burtt, Noel
    Cambien, Francois
    Casari, Giorgio
    Celli, Patrizia
    Chen, Zhen
    Corrocher, Roberto
    Daly, Mark J.
    Deloukas, Panos
    Devaney, Joe
    Do, Ron
    Duga, Stefano
    Elosua, Roberto
    Engert, James C.
    Epstein, Stephen E.
    Erdmann, Jeanette
    Ferrario, Maurizio
    Fetiveau, Raffaela
    Fischer, Marcus
    Friedlander, Yechiel
    Gabriel, Stacey B.
    Galli, Michele
    Gianniny, Lauren
    Girelli, Domenico
    Grosshennig, Anika
    Guiducci, Candace
    Hakonarson, Hakon H.
    Hall, Alistair S.
    Havulinna, Aki S.
    Hengstenberg, Christian
    Hirschhorn, Joel N.
    Holm, Hilma
    Huge, Andreas
    Kent, Kenneth M.
    Konig, Inke R.
    Korn, Joshua M.
    Li, Mingyao
    [J]. NATURE GENETICS, 2009, 41 (03) : 334 - 341
  • [23] Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Larson, Martin G.
    Atwood, Larry D.
    Benjamin, Emelia J.
    Cupples, L. Adrienne
    D'Agostino, Ralph B., Sr.
    Fox, Caroline S.
    Govindaraju, Diddahally R.
    Guo, Chao-Yu
    Heard-Costa, Nancy L.
    Hwang, Shih-Jen
    Murabito, Joanne M.
    Newton-Cheh, Christopher
    O'Donnell, Christopher J.
    Seshadri, Sudha
    Vasan, Ramachandran S.
    Wang, Thomas J.
    Wolf, Philip A.
    Levy, Daniel
    [J]. BMC MEDICAL GENETICS, 2007, 8
  • [24] A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men
    Liu, S
    Schmitz, C
    Stampfer, MJ
    Sacks, F
    Hennekens, CH
    Lindpaintner, K
    Ridker, PM
    [J]. ATHEROSCLEROSIS, 2002, 161 (02) : 469 - 474
  • [25] Phenotypic Overlap of Cardiac Sodium Channelopathies Individual-Specific or Mutation-Specific?
    Makita, Naomasa
    [J]. CIRCULATION JOURNAL, 2009, 73 (05) : 810 - 817
  • [26] The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies
    Marchiori, Antonio
    Mosena, Laura
    Prins, Martin H.
    Prandoni, Paolo
    [J]. HAEMATOLOGICA, 2007, 92 (08) : 1107 - 1114
  • [27] A common allele on chromosome 9 associated with coronary heart disease
    McPherson, Ruth
    Pertsemlidis, Alexander
    Kavaslar, Nihan
    Stewart, Alexandre F. R.
    Roberts, Robert
    Cox, David R.
    Hinds, David A.
    Pennacchio, Len A.
    Tybjaerg-Hansen, Anne
    Folsom, Aaron R.
    Boerwinkle, Eric
    Hobbs, Helen H.
    Cohen, Jonathan C.
    [J]. SCIENCE, 2007, 316 (5830) : 1488 - 1491
  • [28] Genetic inflammatory factors predict restenosis after percutaneous coronary interventions
    Monraats, PS
    Pires, NMM
    Agema, WRP
    Zwinderman, AH
    Schepers, A
    de Maat, MPM
    Doevendans, PA
    de Winter, RJ
    Tio, RA
    Waltenberger, J
    Frants, RR
    Quax, PHA
    van Vlijmen, BJM
    Atsma, DE
    van der Laarse, A
    van der Wall, EE
    Jukema, JW
    [J]. CIRCULATION, 2005, 112 (16) : 2417 - 2425
  • [29] Genome-wide association study identifies eight loci associated with blood pressure
    Newton-Cheh, Christopher
    Johnson, Toby
    Gateva, Vesela
    Tobin, Martin D.
    Bochud, Murielle
    Coin, Lachlan
    Najjar, Samer S.
    Zhao, Jing Hua
    Heath, Simon C.
    Eyheramendy, Susana
    Papadakis, Konstantinos
    Voight, Benjamin F.
    Scott, Laura J.
    Zhang, Feng
    Farrall, Martin
    Tanaka, Toshiko
    Wallace, Chris
    Chambers, John C.
    Khaw, Kay-Tee
    Nilsson, Peter
    van der Harst, Pim
    Polidoro, Silvia
    Grobbee, Diederick E.
    Onland-Moret, N. Charlotte
    Bots, Michiel L.
    Wain, Louise V.
    Elliott, Katherine S.
    Teumer, Alexander
    Luan, Jian'an
    Lucas, Gavin
    Kuusisto, Johanna
    Burton, Paul R.
    Hadley, David
    McArdle, Wendy L.
    Brown, Morris
    Dominiczak, Anna
    Newhouse, Stephen J.
    Samani, Nilesh J.
    Webster, John
    Zeggini, Eleftheria
    Beckmann, Jacques S.
    Bergmann, Sven
    Lim, Noha
    Song, Kijoung
    Vollenweider, Peter
    Waeber, Gerard
    Waterworth, Dawn M.
    Yuan, Xin
    Groop, Leif
    Orho-Melander, Marju
    [J]. NATURE GENETICS, 2009, 41 (06) : 666 - 676
  • [30] Resistance to clopidogrel: A review of the evidence
    Nguyen, TA
    Diodati, JG
    Pharand, C
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (08) : 1157 - 1164
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