Phenolic glycoside constituents from Brassica rapa flowers and their ?-glucosidase inhibitory activity

被引：19

作者：

Zhao, Chun-Chao ^{[1
,2
]}

Shen, Jie ^{[2
]}

Chen, Jia ^{[1
]}

Shao, Jian-Hua ^{[1
]}

Li, Ke-Huan ^{[1
]}

Gu, Wen-Yan ^{[1
]}

Miao, Ben-Jie ^{[1
]}

机构：

[1] Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou, Jiangsu, Peoples R China

[2] Yangzhou Univ, Minist Educ China, Joint Int Res Lab Agr & Agriprod Safety, Yangzhou, Jiangsu, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Brassica rapa L; phenolic glycoside constituents; -glucosidase inhibitory activity; ALPHA-GLUCOSIDASE; LIQUID-CHROMATOGRAPHY; RED CABBAGE; PLANT; ACID;

D O I：

10.1080/14786419.2018.1479704

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new phenolic glycoside compounds (1, 2) and ten known analogues (3?12) have been isolated from the ethanolic extract of Brassica rapa flowers and identified as 2-O-?-d-glucopyranosyl-(1S)-(4-methoxyphenyl)ethylene glycol (1), 2-(4-O-?-d-allopyranosyl)phenyl-ethanol (2), 2-O-?-d-glucopyranosyl-(1S)-phenylethylene glycol (3), 2-O-?-d-glucopyranosyl-(1R)-phenylethylene glycol (4), (Z)-p-coumaryl-O-?-d-glucopyranoside (5), phenyl-O-?-d-glucopyranoside (6), 2-phenylethyl-O-?-d-glucopyranoside (7), salidroside (8), 2-(2-hydroxyphenyl)ethanol-O-?-d-glucopyranoside (9), 4-methoxybenzyl-O-?-d-glucopyranoside (10), 2,4,6-trimethoxyphenyl-1-O-?-d-glucopyranoside (11) and sachaliside 1 (12). The structures of 1 and 2, including absolute configurations, were determined by spectroscopic data (H-1 NMR, C-13 NMR, HSQC, HMBC and ORD) and chemical methods. In addition, most of them exhibited inhibitory activity with IC50 values ranging from 14.43 to 50.20??M in comparison to the positive control acarbose (IC50?=?15.76??M) in intestinal ?-glucosidase inhibitory activity tests.

引用

页码：3398 / 3403

页数：6

共 26 条

[21] Novel fatty acid esters of p-coumaryl alcohol in epicuticular wax of apple fruit [J].