Canine tumour suppressor gene p53 - Mutation in a case of adenoma of circumanal glands

被引：17

作者：

Mayr, B

Schaffner, W

Botto, I

Reifinger, M

Loupal, G

机构：

[1] VET UNIV VIENNA,INST PATHOL,A-1210 VIENNA,AUSTRIA

[2] RES INST MOL PATHOL,A-1030 VIENNA,AUSTRIA

来源：

VETERINARY RESEARCH COMMUNICATIONS | 1997年 / 21卷 / 05期

关键词：

adenoma; circumanal gland; dog; gene; mutation; p53; tumours;

D O I：

10.1023/A:1005820607258

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Highly conserved regions of the tumour suppressor gene p53, including the typical human tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were investigated in various canine neoplasms. A mutation CGG --> TGG (arginine --> tryptophan) was detected in codon 249 in an adenoma of the circumanal gland.

引用

页码：369 / 373

页数：5

共 7 条

[1] P53 MUTATIONS, ANOTHER BREAST-CANCER PROGNOSTIC FACTOR [J].