Kinetics of the lamellar gel-fluid transition in phosphatidylcholine membranes in the presence of sugars

被引：15

作者：

Lenne, Thomas ^{[1
]}

Garvey, Christopher J. ^{[2
]}

Koster, Karen L. ^{[3
]}

Bryant, Gary ^{[1
]}

机构：

[1] RMIT Univ, Melbourne, Vic 3001, Australia

[2] Australian Nucl Sci & Technol Org, Menai, NSW 2234, Australia

[3] Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2010年 / 163卷 / 02期

基金：

美国国家科学基金会;

关键词：

Phospholipids; Lipid phase transitions; Sugars; Desiccation; Freezing; Small angle X-ray scattering; X-RAY-DIFFRACTION; LOW WATER-CONTENT; PHASE-TRANSITION; LIQUID-CRYSTAL; DIPALMITOYLPHOSPHATIDYLCHOLINE MULTILAYERS; GLASS-TRANSITION; SALT SOLUTIONS; LIPID BILAYER; LOW HYDRATION; TREHALOSE;

D O I：

10.1016/j.chemphyslip.2009.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phase diagrams are presented for dipalmitoylphosphatidylcholine (DPPC) in the presence of sugars (sucrose) over a wide range of relative humidities (RHs). The phase information presented here, determined by small angle X-ray scattering (SAXS), is shown to be consistent with previous results achieved by differential scanning calorimetry (DSC). Both techniques show a significant effect of sucrose concentration on the phase behaviour of this phospholipid bilayer. An experimental investigation into the effect of sugars on the kinetic behaviour of the gel to fluid transition is also presented showing that increasing the sugar content appears to slightly increase the rate at which the transition occurs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：236 / 242

页数：7

共 49 条

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