BRCA1 and BRCA2 -: breast cancer susceptibility genes

被引：30

作者：

Hofmann, W

Schlag, PM

机构：

[1] Robert Roessle Hosp, Dept Surg & Surg Oncol, D-13122 Berlin, Germany

[2] Max Delbruck Ctr Mol Med, Dept Tumor Genet, D-13092 Berlin, Germany

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2000年 / 126卷 / 09期

关键词：

BRCA1; BRCA2; breast cancer; genetic predisposition;

D O I：

10.1007/s004320000140

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic predisposition is responsible for 5%-10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the current genetic testing for mutations in both genes are the basis for estimating disease risks for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer.

引用

页码：487 / 496

页数：10

共 103 条

[1]

Abeliovich D, 1997, AM J HUM GENET, V60, P505

[2] BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase a [J].

Anderson, SE ;

Schlegel, BP ;

Nakajima, T ;

Wolpin, ES ;

Parvin, JD .

NATURE GENETICS, 1998, 19 (03) :254-256

[3] BRCA1-associated growth arrest is RB-dependent [J].

Aprelikova, ON ;

Fang, BS ;

Meissner, EG ;

Cotter, S ;

Campbell, M ;

Kuthiala, A ;

Bessho, M ;

Jensen, RA ;

Liu, ET .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :11866-11871

[4]

Berman DB, 1996, CANCER RES, V56, P3409

[5] Increased risk for cancer in patients with the Peutz-Jeghers syndrome [J].

Boardman, LA ;

Thibodeau, SN ;

Schaid, DJ ;

Lindor, NM ;

McDonnell, SK ;

Burgart, LJ ;

Ahlquist, DA ;

Podratz, KC ;

Pittelkow, M ;

Hartmann, LC .

ANNALS OF INTERNAL MEDICINE, 1998, 128 (11) :896-+

[6] Internal repeats in the BRCA2 protein sequence [J].

Bork, P ;

Blomberg, N ;

Nilges, M .

NATURE GENETICS, 1996, 13 (01) :22-23

[7] Breast-cancer diagnosis using hair [J].

Briki, F ;

Busson, B ;

Salicru, B ;

Estève, F ;

Doucet, J .

NATURE, 1999, 400 (6741) :226-226

[8] Recommendations for follow-up care of individuals with an inherited predisposition to cancer .2. BRCA1 and BRCA2 [J].

Burke, W ;

Daly, M ;

Garber, J ;

Botkin, J ;

Kahn, MJE ;

Lynch, P ;

McTierman, A ;

Offit, K ;

Perlman, J ;

Petersen, G ;

Thomson, E ;

Varricchio, C .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (12) :997-1003

[9] New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase AKT pathway [J].

Cantley, LC ;

Neel, BG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4240-4245

[10]

Casey Graham, 1997, Current Opinion in Oncology, V9, P88

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