Genetic evaluation of suspected cases of transient HIV-1 infection of infants

被引：52

作者：

Frenkel, LM

Mullins, JI

Learn, GH

Manns-Arcuino, L

Herring, BL

Kalish, ML

Steketee, RW

Thea, DM

Nichols, JE

Liu, SL

Harmache, A

He, X

Muthui, D

Madan, A

Hood, L

Haase, AT

Zupancic, M

Staskus, K

Wolinsky, S

Krogstad, P

Zhao, JQ

Chen, I

Koup, R

Ho, D

Korber, B

Apple, RJ

Coombs, RW

Pahwa, S

Roberts, NJ

机构：

[1] Univ Washington, Dept Pediat, Div Infect Dis, Seattle, WA 98105 USA

[2] Univ Rochester, Dept Pediat, Rochester, NY 14642 USA

[3] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Med, Seattle, WA 98195 USA

[5] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[6] Med & Hlth Res Assoc New York City, New York, NY 10013 USA

[7] Univ Rochester, Dept Med, Rochester, NY 14642 USA

[8] Univ Texas, Med Branch, Dept Med & Microbiol & Immunol, Galveston, TX 77555 USA

[9] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

[10] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA

[11] Northwestern Univ, Dept Med, Chicago, IL 60611 USA

[12] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA

[13] Univ Calif Los Angeles, Dept Med & Microbiol & Immunol, Los Angeles, CA 90024 USA

[14] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[15] Santa Fe Inst, Los Alamos, NM 87545 USA

[16] Roche Mol Diagnost, Alameda, CA 94501 USA

[17] NYU, N Shore Hosp, Dept Pediat, Manhasset, NY 11030 USA

来源：

SCIENCE | 1998年 / 280卷 / 5366期

关键词：

D O I：

10.1126/science.280.5366.1073

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

引用

页码：1073 / 1077

页数：5

共 22 条

[1] LYMPHOCYTE PROLIFERATIVE RESPONSES TO HIV-1 ENVELOPE AND CORE ANTIGENS BY INFECTED AND UNINFECTED ADULTS AND CHILDREN [J].

BORKOWSKY, W ;

KRASINSKI, K ;

MOORE, T ;

PAPAEVANGELOU, V .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (05) :673-678

[2] CLEARANCE OF HIV-INFECTION IN A PERINATALLY INFECTED INFANT [J].

BRYSON, YJ ;

PANG, S ;

WEI, LS ;

DICKOVER, R ;

DIAGNE, A ;

CHEN, ISY .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (13) :833-838

[3] Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the Prevention of HIV Transmission from Mother to Infant [J].

Cao, YZ ;

Krogstad, P ;

Korber, BT ;

Koup, RA ;

Muldoon, M ;

Macken, C ;

Song, JL ;

Jin, ZQ ;

Zhao, JQ ;

Clapp, S ;

Chen, ISY ;

Ho, DD ;

Ammann, AJ ;

Mullins, J ;

Walker, B ;

Wolinsky, S ;

Bardeguez, A ;

Crane, M ;

Hanson, C ;

Hamill, H ;

Luzuriaga, K ;

Palumbo, P ;

VanDyke, R ;

Widmayer, S ;

Wiznia, A .

NATURE MEDICINE, 1997, 3 (05) :549-552

[4]

CONNOR EM, 1995, PEDIATR INFECT DIS J, V14, P536, DOI 10.1097/00006454-199506000-00012

[5] Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes [J].

Contag, CH ;

Ehrnst, A ;

Duda, J ;

Bohlin, AB ;

Lindgren, S ;

Learn, GH ;

Mullins, JI .

JOURNAL OF VIROLOGY, 1997, 71 (02) :1292-1300

[6] GENETIC-RELATIONSHIPS DETERMINED BY A DNA HETERODUPLEX MOBILITY ASSAY - ANALYSIS OF HIV-1 ENV GENES [J].

DELWART, EL ;

SHPAER, EG ;

LOUWAGIE, J ;

MCCUTCHAN, FE ;

GREZ, M ;

RUBSAMENWAIGMANN, H ;

MULLINS, JI .

SCIENCE, 1993, 262 (5137) :1257-1261

[7]

DELWART EL, 1995, AIDS RES HUM RETROV, V11, P1181

[8] EFFECTS OF ZIDOVUDINE USE DURING PREGNANCY ON RESISTANCE AND VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

FRENKEL, LM ;

WAGNER, LE ;

DEMETER, LM ;

DEWHURST, S ;

COOMBS, RW ;

MURANTE, BL ;

REICHMAN, RC .

CLINICAL INFECTIOUS DISEASES, 1995, 20 (05) :1321-1326

[9]

FRENKEL LM, UNPUB

[10]

HOFFENBACH A, 1989, J IMMUNOL, V142, P452

← 1 2 3 →