Esophageal Second Primary Tumors in Patients With Head and Neck Squamous Cell Carcinoma: Incidence, Risk Factors, and Overall Survival

被引：3
|
作者：
Overwater, Anouk [1 ,2 ]
Rueb, Kuna [2 ]
Elias, Sjoerd G. [3 ]
de Bree, Remco [4 ]
Weusten, Bas L. A. M. [1 ,2 ]
机构：
[1] St Antonius Hosp, Dept Gastroenterol & Hepatol, Nieuwegein, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands
[3] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
[4] Univ Utrecht, Univ Med Ctr Utrecht, Dept Head & Neck Surg Oncol, Utrecht, Netherlands
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2022年 / 117卷 / 05期
关键词：
CANCER;
D O I：
10.14309/ajg.0000000000001711
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
INTRODUCTION: The aim of this registry-based cohort study was to evaluate the potential role of endoscopic esophageal surveillance for esophageal second primary tumors (ESPTs) in Western patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Outcomes were cumulative incidence and risk factors for ESPTs and its effect on overall survival. RESULTS: A total of 47 ESPTs were observed in 1,708 patients with HNSCC, with 10-year cumulative incidence (95% confidence interval) of 2.9% (2.1-3.7). Alcohol and HNSCC location were significant predictors for ESPTs. ESPTs significantly increased the risk of dying (adjusted hazard ratio 3.36, 95% confidence interval 2.16-5.22). DISCUSSION: Endoscopic esophageal surveillance of Western patients with HNSCC with high risk of ESPTs seems justified.
引用
收藏
页码：794 / 797
页数：4
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