TARP as antigen in cancer immunotherapy

被引：3
作者：
Vanhooren, Jolien [1 ,2 ,3 ]
Derpoorter, Charlotte [1 ,2 ,3 ]
Depreter, Barbara [4 ]
Deneweth, Larissa [1 ,2 ,3 ]
Philippe, Jan [3 ,5 ]
De Moerloose, Barbara [1 ,2 ,3 ]
Lammens, Tim [1 ,2 ,3 ]
机构：
[1] Ghent Univ Hosp, Dept Pediat Hematol Oncol & Stem Cell Transplanta, Ghent, Belgium
[2] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium
[3] Canc Res Inst Ghent CRIG, Ghent, Belgium
[4] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel, Dept Haematol, Brussels, Belgium
[5] Ghent Univ Hosp, Dept Diagnost Sci, Ghent, Belgium
来源：
CANCER IMMUNOLOGY IMMUNOTHERAPY | 2021年 / 70卷 / 11期
关键词：
TARP; Cancer-associated antigen; Immunotherapy; T-CELL-RECEPTOR; ALTERNATE READING FRAME; TUMOR-ASSOCIATED ANTIGEN; PROTEIN TARP; PROGNOSTIC-SIGNIFICANCE; HUMAN PROSTATE; BREAST; EXPRESSION; ANTIBODIES; GENE;
D O I：
10.1007/s00262-021-02972-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In recent decades, immunotherapy has become a pivotal element in cancer treatment. A remaining challenge is the identification of cancer-associated antigens suitable as targets for immunotherapeutics with potent on-target and few off-tumor effects. The T-cell receptor gamma (TCR gamma) chain alternate reading frame protein (TARP) was first discovered in the human prostate and androgen-sensitive prostate cancer. Thereafter, TARP was also identified in breast and endometrial cancers, salivary gland tumors, and pediatric and adult acute myeloid leukemia. Interestingly, TARP promotes tumor cell proliferation and migration, which is reflected in an association with worse survival. TARP expression in malignant cells, its role in oncogenesis, and its limited expression in normal tissues raised interest in its potential utility as a therapeutic target, and led to development of immunotherapeutic targeting strategies. In this review, we provide an overview of TARP expression, its role in different cancer types, and currently investigated TARP-directed immunotherapeutic options.
引用
收藏
页码：3061 / 3068
页数：8
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