Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy

被引：107

作者：

Inder, TE

Hunt, RW

Morley, CJ

Coleman, L

Stewart, M

Doyle, LW

Jacobs, SE

机构：

[1] Royal Childrens Hosp, Parkville, Vic 3052, Australia

[2] Royal Hosp Women, Div Newborn Serv, Melbourne, Vic, Australia

[3] Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[4] Royal Childrens Hosp, Dept Med Imaging, Melbourne, Vic, Australia

[5] Univ Melbourne, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

来源：

JOURNAL OF PEDIATRICS | 2004年 / 145卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.jpeds.2004.07.034

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.

引用

收藏

页码：835 / 837

页数：3

相关论文

共 13 条

[1] Pilot study of treatment with whole body hypothermia for neonatal encephalopathy [J].

Azzopardi, D ;

Robertson, NJ ;

Cowan, FM ;

Rutherford, MA ;

Rampling, M ;

Edwards, AD .

PEDIATRICS, 2000, 106 (04) :684-694

[2] EXCITATORY AMINO-ACIDS CONTRIBUTE TO THE PATHOGENESIS OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY [J].

BARKS, JDE ;

SILVERSTEIN, FS .

BRAIN PATHOLOGY, 1992, 2 (03) :235-243

[3] Treatment of term infants with head cooling and mild systemic hypothermia (35.0°C and 34.5°C) after perinatal asphyxia [J].

Battin, MR ;

Penrice, J ;

Gunn, TR ;

Gunn, AJ .

PEDIATRICS, 2003, 111 (02) :244-251

[4] Combined use of electroencephalogram and magnetic resonance imaging in full-term neonates with acute encephalopathy [J].

Biagioni, E ;

Mercuri, E ;

Rutherford, M ;

Cowan, F ;

Azzopardi, D ;

Frisone, MF ;

Cioni, G ;

Dubowitz, L .

PEDIATRICS, 2001, 107 (03) :461-468

[5] EFFECT OF MILD HYPOTHERMIA ON ISCHEMIA-INDUCED RELEASE OF NEUROTRANSMITTERS AND FREE FATTY-ACIDS IN RAT-BRAIN [J].

BUSTO, R ;

GLOBUS, MY ;

DIETRICH, WD ;

MARTINEZ, E ;

VALDES, I ;

GINSBERG, MD .

STROKE, 1989, 20 (07) :904-910

[6] Hypothermia reduces neurological damage in asphyxiated newborn infants [J].

Compagnoni, G ;

Pogliani, L ;

Lista, G ;

Castoldi, F ;

Fontana, P ;

Mosca, F .

BIOLOGY OF THE NEONATE, 2002, 82 (04) :222-227

[7] Whole-body cooling after perinatal asphyxia: a pilot study in term neonates [J].

Debillon, T ;

Daoud, P ;

Durand, P ;

Cantagrel, S ;

Jouvet, P ;

Saizou, C ;

Zupan, V .

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2003, 45 (01) :17-23

[8] Hypoxic-ischemic brain injury in the newborn - Cellular mechanisms and potential strategies for neuroprotection [J].

duPlessis, AJ ;

Johnston, MV .

CLINICS IN PERINATOLOGY, 1997, 24 (03) :627-+

[9] Brain temperature in newborn piglets under selective head cooling with minimal systemic hypothermia [J].

Iwata, O ;

Iwata, S ;

Tamura, M ;

Nakamura, T ;

Sugiura, M ;

Ogiso, Y .

PEDIATRICS INTERNATIONAL, 2003, 45 (02) :163-168

[10] Therapeutic hypothermia after cardiac arrest [J].

Safar, PJ ;

Kochanek, PM .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (08) :612-613