Small-molecule natural products: new structures, new activities

被引：55
作者：
Baker, DD
Alvi, KA
机构：
[1] Cubist Pharmaceut Inc, Lexington, MA 02421 USA
[2] Albany Mol Res Inc, Bothell Res Ctr, Bothell, WA 98011 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2004年 / 15卷 / 06期
关键词：
D O I：
10.1016/j.copbio.2004.09.003
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A wide variety of novel small-molecule natural products has recently been reported. These compounds were isolated from marine and terrestrial sources, and from a variety of animals, plants and microorganisms. With the breadth of diversity represented in these bioactive small molecules, the future of natural product drug discovery looks bright.
引用
收藏
页码：576 / 583
页数：8
相关论文
共 45 条
[1]   Kottamides A-D:: Novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae [J].
Appleton, DR ;
Page, MJ ;
Lambert, G ;
Berridge, MV ;
Copp, BR .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (15) :5402-5404
[2]   The leupyrrins:: A structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum [J].
Bode, HB ;
Irschik, H ;
Wenzel, SC ;
Reichenbach, H ;
Müller, R ;
Höfle, G .
JOURNAL OF NATURAL PRODUCTS, 2003, 66 (09) :1203-1206
[3]   Brocaenols A-C:: Novel polyketides from a marine-derived Penicillium brocae [J].
Bugni, TS ;
Bernan, VS ;
Greenstein, M ;
Janso, JE ;
Maiese, WM ;
Mayne, CL ;
Ireland, CM .
JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (05) :2014-2017
[4]   Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor [J].
Fitch, RW ;
Garraffo, HM ;
Spande, TF ;
Yeh, HJC ;
Daly, JW .
JOURNAL OF NATURAL PRODUCTS, 2003, 66 (10) :1345-1350
[5]  
Goetz G. H., 2003, Patent No. [PCT WO 03/051831, 03051831]
[6]  
GOETZ GH, 2003, Patent No. 02200001
[7]  
Huang L., 1984, ALKALOIDS, V23, P157
[8]   ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490I.: Taxonomy, fermentation, isolation and biological activities [J].
Inoue, H ;
Kumagai, H ;
Osono, M ;
Matsufuji, M ;
Sameshima, T ;
Kawamura, N ;
Someno, T ;
Ishizuka, M ;
Takeuchi, T .
JOURNAL OF ANTIBIOTICS, 2003, 56 (03) :209-213
[9]   Daphcalycine, a novel heptacycle fused ring system alkaloid from Daphniphyllum calycinum [J].
Jossang, A ;
El Bitar, H ;
Pham, VC ;
Sévenet, T .
JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (02) :300-304
[10]  
KIJIMA M, 1993, J BIOL CHEM, V268, P22429
12345