Resolution of (±)-ibuprofen using (-)-brucine as a chiral selector by thin layer chromatography

被引：16

作者：

Bhushan, R ^{[1
]}

Gupta, D ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

来源：

BIOMEDICAL CHROMATOGRAPHY | 2004年 / 18卷 / 10期

关键词：

enantiomeric separation; (+/-)-ibuprofen; (-)-brucine; normal phase TLC;

D O I：

10.1002/bmc.398

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric resolution of (+/-)-ibuprofen into its enantiomers was achieved by TLC on silica gel plate using optically pure (-)-brucine as a chiral selector and acetonitrile-methanol (5:1, v/v) as the solvent system. Spots were located in an iodine chamber. The detection limit was 4.9 mug. The effect of concentration of the chiral selector, temperature and pH on resolution has been studied. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：838 / 840

页数：3

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